similar to: Request for Assistance in R with NonMem

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Hello, I have made an R script that prepares a NONMEM dataset and I would like to start the NONMEM run right after the dataset is ready. I am using windows XP, R 2.9.1 and NONMEM 6. I have prepared a run.bat file that looks like this: ---------------------------------------- call K:\nmvi\NMdirectories.bat call K:\nmvi\nmfe6 "path\control.txt" "path\output.txt"

Dear R users, I am using nlme to fit a pharmacokinetic model. The base model is parameterized in terms of CL, V1, V2 and Q. basemodel<-nlme(Conc ~TwoCompModel(CL,Q,V1,V2,Time,ID), data = data2, fixed=list(CL+Q+V1+V2~1), random = pdDiag(CL+V1+V2~1), start=c(CL=log(20),Q=log(252),V1=log(24.9),V2=log(120)), control=list(returnObject=TRUE,msVerbose=TRUE, msMaxIter=20,pnlsMaxIter=20,pnlsTol=1),

Dear group, I am trying to prepare a NONMEM friendly dataset for population PK analysis. My patient IDs are 10 digit long and NONMEM is losing precison and rouding the last couple of digits. I need to generate unique Patient IDs fromt he current 10-digit IDs. Ihave total 250 subjects so I appreciate if anybody can suggest me a way to code this in R. Regards, Ayyappa [[alternative HTML

Dear R-users, Do you know if we can use the function lme in R for log-normal distribution of parameters as used in Nonmem ? theta=theta0*exp(eta) In our model, the parameters follow the log-normal distribution so it's not reasonable to deal with normal distribution which gives us negative values in simulation Thanks for your help, Thu [[alternative HTML version deleted]]

Dear All, I want to create a dataset for a NONMEM simulation. I have a dataframe with individual PK parameters and want to create a dosing sceinario in a second dataframe. I want to merge them both so that every individiual's PK parameters are combined with the dosing scenario into one. I do not have a common variable to merge and cbind is giving error that lengths are different. I

Greetings, I used latex type code in my Rd files. The pdf version using R CMD Rd2dvi --output=PKtools.pdf --pdf --title="PKtools" PKtools man came out quite nice. However, my current HTML version does not tex the latex so there is latex code in the files and looks bad. example problem code: AIC$_c$ or \begin{itemize} \item NLME: \begin{itemize} \item population level:

Hi,all, when I run the below code,there is an error occured. could you please tell me how to treat it? > pdf('covariate.pdf') > par(mfrow=c(1,1)) > pairs(data2[,c("ID","TYPE","AGE","GNDR","HT")], + panel=function(x,y) { points(x,y); lines(lowess(x,y))}) Error in `[.data.frame`(data2, , c("ID", "TYPE",

Hi, when I run the below code,there is an error occured. could you please tell me how to treat it? > pdf('covariate.pdf') > par(mfrow=c(1,1)) > pairs(data2[,c("ID","TYPE","AGE","GNDR","HT")], + panel=function(x,y) { points(x,y); lines(lowess(x,y))}) Error in `[.data.frame`(data2, , c("ID", "TYPE",

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Hi Everyone: I am running NONMEM from R using following command. shell("nmfe72 TOT_EST_DOSE2.CTL DOSE2.OUT",wait=T) This command runs NONMEM successfully but does not show the progress. Usually, intermediate outputs are displayed on CMD console when this same command is run from CMD console. How can I view the intermediate outputs while running NONMEM from R?

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TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PKPD modelling platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a collaborative effort of four excellent academic institutes and six leading global pharmaceutical industries. Unique to this platform is the availability of shared databases on

Two Postdoctoral fellows (fulltime) Leiden University, Leiden, The Netherlands Job description ________________________________________ TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PK-PD modelling platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a collaborative effort of

________________________________ Principal Post-Doctoral Fellow PKPD modelling platform (full time) Leiden University, Leiden, The Netherlands <javascript:doredirect();> Job description ________________________________ TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PK-PD modelling platform. This platform focuses on the transfer of

Post-Doctoral Fellowship Modelling of Cardiovascular Safety (full time) Leiden University, Leiden, The Netherlands <javascript:doredirect();> Job description TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PKPD modelling platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a

Hi, My platform is Ubuntu 12.04. The hostname is puppet and this is a Virtual Machine in Vmware 5.0. This is a lab server and it is behind a proxy. I am having a problem with the installer. Any ideas what is going on? root@puppet:/home/rbgonza/puppet/puppet-enterprise-2.8.0-all# ./puppet-enterprise-installer

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