search for: relapses

Hello R-community, It's been a week now that I am struggling with the implementation of a cox model in R. I have 80 cancer patients, so 80 time measurements and 80 relapse or no measurements (respective to censor, 1 if relapsed over the examined period, 0 if not). My microarray data contain around 18000 genes. So I have the expressions of 18000 genes in each of the 80 tumors (matrix

Dear friends: I'm interested to make a stacked plot of cumulative incidence. that's, the cuminc model is fitted [fit=cuminc(time, relapse)] and cumulative incidence is in place. I'd like to stack the cuminc plots (relapse of luekemia and death free from leukemia, for example) , then the constituent ratio of leukemia relapse and treatment related mortality is very clear. Can

Hello everyone, I am a very new user of R and I have a query about the cuminc function in the package cmprsk. In particular I would like to verify that I am interpreting the output correctly when we have a stratification variable. Hypothetical example: group : fair hair, dark hair fstatus: 1=Relapse, 2=TRM, 0=censored strata: sex (M or F) Our data would be split into: Fair, male,

Dear list, I am not familiar with survival analysis and I would need your help to understand a result I have obtained. I have used the following command line to look at number of events and probability of survival at the first 5 years: > su = summary(survfit(Surv(a[, Date], a[, Event]) ~ strata(a[,Prediction]), data = a), times=c(0,1,2,3,4,5)) I have studied two kind of events (disease-free

Hello everyone,   I am a very new user of R and I have a query about the cuminc function in the package cmprsk. In particular I would like to verify that I am interpreting the output correctly when we have a stratification variable.   Hypothetical example:   group : fair hair, dark hair fstatus: 1=Relapse, 2=TRM, 0=censored strata: sex (M or F)   Our data would be split into:   Fair, male,

Dear R users, I d like to assess the effect of "treatment" covariate on a disease relapse risk with the package cmprsk. However, the effect of this covariate on survival is time-dependent (assessed with cox.zph): no significant effect during the first year of follow-up, then after 1 year a favorable effect is observed on survival (step function might be the correct way to say that ?).

Hello, I have a problem regarding calculation of Cumulative Incidence Function. The event of interest is failure of bone-marrow transplantation, which may occur due to relapse or death in remission. The data set that I have consists of- lifetime variable, two indicator variables-one for relapse and one for death in remission, and the other variables are donor type (having 3 categories), disease

Dear list, I am trying to build a cox model and then perform ROC analysis in order to retrieve some genes that are correlated with breast cancer. When I calculate the hazard score taking into account different numbers of genes and their coefficients ( I am trying to find the pest predictor number of genes), I retrieve from around 1 values (for few genes included ) to size of e+80 values (for many

Hi Bert, I am sorry to bother you on weekend. I am still struggling on defining a correct function. I first defined the function RFS (see below), then run it by provide the two argument. m52.2cluster <-RFS(inputfile =allinfo_m52, N=2 ) I do not get error message, but no figure displays on screen. I do not know what is going on. Can you help me a little more on this issue? Thank you,

Dear R users, I d like to assess the effect of "treatment" covariate on a disease relapse risk with the package cmprsk. However, the effect of this covariate on survival is time-dependent (assessed with cox.zph): no significant effect during the first year of follow-up, then after 1 year a favorable effect is observed on survival (step function might be the correct way to say that

Hi Richard, Thank you so much!! I understand the problem now, I assign a name to the "ggsurvplot" object and then add print(fig) at bottom of function definition, now figure gets printed on screen. Ding # function to generate RFS curves RFS <- function( inputfile, N ) { cluster<- survfit(Surv(RFS_days2, OV_Had_a_Recurrence_CODE) ~ clusters, data =

Dear list, I am trying to perform a significance analysis of a microarray experiment with survival data using the {samr} package. I have a matrix containing my data which has 17816 rows corresponding to genes, and 286 columns corresponding to samples. The name of this matrix is data.matrix2. Some of the first values of this matrix are: data.matrix2[1:3,1:5] GSM36777 GSM36778 GSM36779

FAQ 7.22 You must print a ggplot object, for example with print(m52.2cluster) For the FAQ, run the line system.file("../../doc/FAQ") in R on your computer. Open up the resulting filepath in your favorite editor and scroll down to 7.22 On Sun, Jan 14, 2018 at 4:21 PM, Ding, Yuan Chun <ycding at coh.org> wrote: > Hi Bert, > > I am sorry to bother you on weekend. >

Hello R users, I am trying to run a cox model for the prediction of relapse of 80 cancer tumors, taking into account the expression of 17000 genes. The data are large and I retrieve an error: "Cannot allocate vector of 2.4 Mb". I increase the memory.limit to 4000 (which is the largest supported by my computer) but I still retrieve the error because of other big variables that I have in

That is certainly OK, but you can also just use print(ggsurvplot(...)) as your final statement. out <- RFS( ...) would then return the ggsurvplot object *and* graph it. Any good R tutorial or a web search will provide more details on function returns, which you might find useful. Cheers, Bert Bert Gunter "The trouble with having an open mind is that people keep coming along and

Thank you, your suggestion is simpler and logically better. I had impression that the last object in a function gets returned, so I did not add the print function at the bottom line of the function definition. Returning an object and graph the object are different process, I am a beginner for writing R function and need to find a good guide source about writing R functions. If you know a good

I'm trying to categorize a continuous variable (yes, I know that's horrible, but I'm trying to reproduce some exercises from a textbook) and don't really know an efficient way to do this. I have a data frame that looks like: surv_time relapse sex log_WBC rx 1 35 0 1 1.45 0 2 34 0 1 1.47 0 3 32 0 1 2.20 0 4 32

Hello again, I m trying to use timereg package as you suggested (R2.7.1 on XP Pro). here is my script based on the example from timereg for a fine & gray model in which relt = time to event, rels = status 0/1/2 2=competing, 1=event of interest, 0=censored random = covariate I want to test library(timereg) rel<-read.csv("relapse2.csv", header = TRUE, sep = ",",

HI R users, I construct dendrogram tree and cut the tree into different clusters, then generate survival curves by the following three functions. All variables are included in an inputfile. Can you help me to consolidate the following three function into one functions? I thought about using if else function, but not sure how to do it. Thank you, Ding # function to generate RFS RFS2cluster

For any given pre-specified gene or short list of genes, yes the Cox model works fine. Two important caveats: 1. Remeber the rule of thumb for a Cox model of 20 events per variable (not n=20). Many microarray studies will have very marginal sample size. 2. If you are looking at many genes then a completely different strategy is required. There is a large and growing literature; I like Newton