search for: pharmacokinet

Pharmacokinetic and pharmacodynamic modeling and simulation By Dr. Jan Freijer September 24, 2009 Amsterdam, The Netherlands http://www.can.nl/events/details.php?id=57 This course is aimed at users of R or S-PLUS in the bio-pharmaceutical sciences who would like to use R for clinical tr...

Hi, I just wonder if R is still used for PK analysis. However, I have to use R for some purposes anyways. Here is a really strange problem I am running into and I hope to get some assistance from the group. The following code works fine in S-Plus (Population estimates and MAP estimates look reasonable ). cs.fit<-nlme ( CONC~phenoModel(CID,TIME, DOSE, lCl, lV), fixed = lCl+lV ~1,

Dear All, I like to simulate a physiologically based pharmacokinetics model using R but am having a problem with the daspk routine. The same problem has been implemented in Berkeley madonna and Winbugs so that I know that it is working. However, with daspk it is not, and the numbers are everywhere! Please see the following and let me know if I am missing somethi...

...eaves xaxp reset when it exits: par(xaxp=c(0,1,4)) print(par("xaxp")) plot(c(0,1),c(0.2,0.3)) print(par("xaxp")) R. Woodrow Setzer, Jr. Phone: (919) 541-0128 Experimental Toxicology Division Fax: (919) 541-5394 Pharmacokinetics Branch NHEERL MD-74; US EPA; RTP, NC 27711 -.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.- r-help mailing list -- Read http://www.ci.tuwien.ac.at/~hornik/R/R-FAQ.html Send "info", "help", or "[un]subscribe" (in the "body",...

....default(c(formals(f), value), envir) : invalid formal argument list for "function" Can someone give me a simple example for doing this? Thanks! R. Woodrow Setzer, Jr. Phone: (919) 541-0128 Experimental Toxicology Division Fax: (919) 541-4284 Pharmacokinetics Branch NHEERL B143-05; US EPA; RTP, NC 27711

All, I am constructing a pharmacokinetic dataset and have hit a snag. The dataset can be demonstrated in the following way: myData <- data.frame( evid = c(1, 0, 0, 0, 1, 0, 1, 1, 1, 0), time = 1:10, last.dose.time = c(1, 1, 1, 1, 5, 5, 7, 8, 9, 9) ) The evid field is an indicator variable for whether the associated observati...

...is possible, or should I pass a string through to the compiled code, and find the pointer on that side (and how to do that)? Thanks. R. Woodrow Setzer, Jr. Phone: (919) 541-0128 Experimental Toxicology Division Fax: (919) 541-5394 Pharmacokinetics Branch NHEERL MD-74; US EPA; RTP, NC 27711 -.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.- r-help mailing list -- Read http://www.ci.tuwien.ac.at/~hornik/R/R-FAQ.html Send "info", "help", or "[un]subscribe" (in the "body",...

...e = R Windows 2000 Professional (build 2195) Service Pack 2.0 Search Path: .GlobalEnv, package:OPmodels, package:odesolve, package:ctest, Autoloads, package:base R. Woodrow Setzer, Jr. Phone: (919) 541-0128 Experimental Toxicology Division Fax: (919) 541-4284 Pharmacokinetics Branch NHEERL B143-05; US EPA; RTP, NC 27711

...or = 1 minor = 2.1 year = 2001 month = 01 day = 15 language = R Search Path: .GlobalEnv, package:ctest, Autoloads, package:base R. Woodrow Setzer, Jr. Phone: (919) 541-0128 Experimental Toxicology Division Fax: (919) 541-5394 Pharmacokinetics Branch NHEERL MD-74; US EPA; RTP, NC 27711 -.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.- r-help mailing list -- Read http://www.ci.tuwien.ac.at/~hornik/R/R-FAQ.html Send "info", "help", or "[un]subscribe" (in the "body",...

...98 SE 4.10 (build 2222) A Search Path: .GlobalEnv, package:ctest, package:RBMDS, package:nls, package:nlme, Autoloads, package:base R. Woodrow Setzer, Jr. Phone: (919) 541-0128 Experimental Toxicology Division Fax: (919) 541-5394 Pharmacokinetics Branch NHEERL MD-74; US EPA; RTP, NC 27711 -.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.- r-help mailing list -- Read http://www.ci.tuwien.ac.at/~hornik/R/R-FAQ.html Send "info", "help", or "[un]subscribe" (in the "body",...

Dear all, I have two questions: 1. Does anyone know if nlmeODE package will work once odesolve is discontinued? If i understand well nlmeODE depends on odesolve. 2. Can anyone suggest another package I could use to fit complex PKPD models (described using differential equations) to data? Thanks a lot! Magdalena

All, I have been able to successfully use the optim( ) function with "L-BFGS-B" to find reasonable parameters for a one-compartment open pharmacokinetic model. My loss function in this case was squared error, and I made no assumptions about the distribution of the plasma values. The model appeared to fit pretty well. Out of curiosity, I decided to try to use nlminb( ) applied to a likelihood function that assumes the plasma values are normally...

...rch i386 os mingw32 system i386, mingw32 status major 1 minor 5.1 year 2002 month 06 day 17 language R R. Woodrow Setzer, Jr. Phone: (919) 541-0128 Experimental Toxicology Division Fax: (919) 541-5394 Pharmacokinetics Branch NHEERL MD-74; US EPA; RTP, NC 27711 -.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.- r-devel mailing list -- Read http://www.ci.tuwien.ac.at/~hornik/R/R-FAQ.html Send "info", "help", or "[un]subscribe" (in the "body"...

Dear Colleagues, Our group is also working on implementing the use of R for pharmacokinetic compartmental analysis. Perhaps I have missed something, but > fit <- nls(noisy ~ lsoda(xstart, time, one.compartment.model, c(K1=0.5, k2=0.5)), + data=C1.lsoda, + start=list(K1=0.3, k2=0.7), + trace=T + ) Error in eval(as.name(varName), data) :...

...ect Error: Couldn't read page catalog If I eliminate 32 plots, the file renders correctly in xpdf (I haven't tried Acroread). R. Woodrow Setzer, Jr. Phone: (919) 541-0128 Experimental Toxicology Division Fax: (919) 541-5394 Pharmacokinetics Branch NHEERL MD-74; US EPA; RTP, NC 27711 -.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.- r-help mailing list -- Read http://www.ci.tuwien.ac.at/~hornik/R/R-FAQ.html Send "info", "help", or "[un]subscribe" (in the "body",...

Dear R users, I am using nlme to fit a pharmacokinetic model. The base model is parameterized in terms of CL, V1, V2 and Q. basemodel<-nlme(Conc ~TwoCompModel(CL,Q,V1,V2,Time,ID), data = data2, fixed=list(CL+Q+V1+V2~1), random = pdDiag(CL+V1+V2~1), start=c(CL=log(20),Q=log(252),V1=log(24.9),V2=log(120)), control=list(returnObject=TRUE,msVerbose=T...

...nt to change the settings of the current device. This can be done by pointing and clicking on the "history" tab of a graphics device in windows, but I would like to do this in a script. Best regards, Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 Mobile: +46 701 679 048 <http://www.farmbio.uu.se/research.php?avd=5> www.farmbio.uu.se/research.php?avd=5 [[alternative HTML version deleted]]

...es of Major European Stock Indices, 1991-1998 Formaldehyde Determination of Formaldehyde HairEyeColor Hair and Eye Color of Statistics Students Harman23.cor Harman Example 2.3 Harman74.cor Harman Example 7.4 Indometh Pharmacokinetics of Indomethicin InsectSprays Effectiveness of Insect Sprays JohnsonJohnson Quarterly Earnings per Johnson & Johnson Share LakeHuron Level of Lake Huron 1875-1972 LifeCycleSavings Intercountry Life-Cycle Savings Data Loblolly Growth of L...

Pfizer is hiring a statistician supporting early drug discovery for Global Medicinal Chemistry and Pharmacokinetics, Dynamics and Metabolism (PDM). If interested, go to http://pfizercareers.com/ and search for job ID 985944. The location is Groton, Connecticut. Responsibilities The statistician will have a consulting-type role supporting a large pool of scientists in two large platform line groups. Typ...

Hi, I am about to conduct an experiment of temperature dependent development of an insect. Here I would like to know is if I could be able to find the parameters of the models what I will use in data analysis with R program. I have found some other softwares that can be used for parameter estimation but liscence would be needed, not open source. So I prefer to use R langauge if it is reliable