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...es through set of data then produce curve and ic50. Here is my sudo code: For (plateid in platelist) { Input data (plateid) as matrix Curve fitting model4logistic <- multdrc(rdata ~ ld, logDose=10) } The first 3 plates are ok, 4th plate has following error Error in mdrcOpt(opfct, startVec, optMethod, derFlag, constrained, warnVal, : Convergence failed I know the expected fitting is ugly, is it the reason to produce the error? Thanks you in advance for your help, Xin Gong [[alternative HTML version deleted]]

..., -9L), class = "data.frame") # curva # install.packages(''drm'') require(drm, quietly = TRUE, warn.conflicts = FALSE) with(d, plot(dose, y, las = 1)) fit <- drm(y ~ dose, fct = LL.4(), control = drmc(maxIt = 100000, relTol = 1e-4), data = d) # Error in optim(startVec, opfct, hessian = TRUE, method = optMethod, control = list(maxit = maxIt, : # non-finite finite-difference value [4] # Error in drmOpt(opfct, opdfct1, startVecSc, optMethod, constrained, warnVal, : # Convergence failed He cambiado un poco los parametros de control de la funcion drm, pero no ha sido e...

...1e+01 0.00 169 1e+01 0.00 170 1e+01 0.00 171 1e+01 0.00 172 1e+01 0.00 173 1e+01 0.00 174 1e+01 0.00 175 1e+01 0.00 176 1e+01 0.00 177 1e+01 0.00 178 1e+01 0.00 179 1e+01 0.00 180 1e+01 0.00 m1 <- drm(Length ~ conc, data = dat, fct = CRS.4c()) Error in optim(startVec, opfct, hessian = TRUE, method = optMethod, control = list(maxit = maxIt, : non-finite finite-difference value [1] Error in drmOpt(opfct, opdfct1, startVecSc, optMethod, constrained, warnVal, : Convergence failed Thanks in advance Syamkumar R School of Environmental Studies CUSAT Kerala, India