search for: ncrnas

Jenner lab, University College London Our laboratory uses genomics and biochemical techniques to identify how transcription factors, chromatin modifiers and non-coding RNAs act to regulate cell differentiation. Our research has led to the characterisation of a class of short RNAs transcribed from polycomb target genes that interact with polycomb repressive complex-2 (Kanhere et al., Mol Cell

...patterns in gene expression are disrupted in cancer. The project will suit a graduate student from a computational background with exceptional programming ability and strength in mathematics and statistics. The main focus of our group is directed at understanding the role played by noncoding RNAs (ncRNAs) in modulating the behaviour of cancer cells. These are RNA molecules that are transcribed, but never translated into protein sequences. Advances in sequencing technology have revealed large numbers of novel ncRNA loci in the genome, to the point where they are now known to outnumber protein-coding...