search for: cardiovascular

...to make NRI estimates from my Cox models with and without a specific biomarker. According to Pencina et al (Statistics in Medicine 2010, DOI: 0.1002/sim.4085 ), a continuous/non-categorical NRI (NRI>0) is to be used when there are no obvious reason to categorize risk, such as the risk of future cardiovascular events in patients with established cardiovascular disease. My question is therefore: Which value(s) are to be used in the calculation of continuous NRI from the output in Hmisc or in PredictABEL? Does continuous NRI equal total NRI in the output? Yours sincerely Gard Frodahl T. Svingen PhD st...

Hi All: I just use wine to run a windows based program. I think it is successfully installed, but when I run it with WINEDEBUG=warn+all, there are some warning message at the beginning as: warn:file:wine_nt_to_unix_file_name L"wineboot.exe" not found in /home/huifeng/.wine/dosdevices/c:/windows/system32 warn:ntdll:NtQueryFullAttributesFile L"\\??\\C:\\windows\\system32\

...ale_CVD, Female_CVD,Male_RTA,Female_RTA, and so on. For each disease, I want to pull out the column of data containing the word 'Male' and plot this against age, and then add a line to the plot for the corresponding column containing 'Female'. -- attach(data) Diseases <- c("Cardiovascular disease","Road Traffic Injury", ... ,"All causes") Male <- names(data)[grep("Male",names(data))] Female <- names(data)[grep("Female",names(data))] #Disease contains disease labels in the correct order, and Male and Female now hold the (correct) va...

...manuals and vignettes without finding any explicit suggestions on how to operate... Can anyone, please, point my attention to the relevant documentation? Thank you in advance and best regards, Marco -- Marco Manca, MD University of Maastricht Faculty of Health, Medicine and Life Sciences (FHML) Cardiovascular Research Institute (CARIM) PO Box 616 6200 MD Maastricht E-mail: m.manca at path.unimaas.nl Office telephone: +31(0)433874633 Personal mobile: +31(0)626441205 Twitter: @markomanka ********************************************************************************************************************...

...to plot the longitudinal data. One problem is that xyplot() recycles the color of auto.key so that every 7th subject has the same color (symbol if setps() was used). Is there a way so that every subject will have a unique color or symbol? Thanks Osman -- Osman O. Al-Radi, MD, MSc, FRCSC Fellow, Cardiovascular Surgery The Hospital for Sick Children University of Toronto, Canada [[alternative HTML version deleted]]

...anel? library(lattice) x <- rnorm(400) y <- rnorm(400) a <- gl(4, 100) xyplot(y~x|a, panel=function(...){ panel.loess(...) panel.text(0,2,label=c('best','better','bad','worst'))}) Thanks Osman Osman O. Al-Radi, MD, MSc, FRCSC Staff Cardiovascular Surgeon Co-medical director, Tissue Bank The Hospital for Sick Children University of Toronto, Canada [[alternative HTML version deleted]]

...ep=T,p=c(0.99,0.01)), sample(c(0,1),40,rep=T,p=c(0.95,0.05)), sample(c(0,1),2,rep=T,p=c(0.5,0.5)), sample(c(0,1),10,rep=T,p=c(0.9,0.1)), sample(c(0,1),40,rep=T,p=c(0.8,0.2))) df<-data.frame(group=group,outcome=as.numeric(outcome)) Osman O. Al-Radi, MD, MSc, FRCSC Staff Cardiovascular Surgeon Co-medical director, Tissue Bank The Hospital for Sick Children University of Toronto, Canada [[alternative HTML version deleted]]

...the trials I am involved in are one-armed (so there are no across-trial-arms comparisons). No matter how hard I try to explain to physicians why this approach is not the best, it has typically been to no avail. I am wondering if anyone knows of a paper I can quote instead? One (or more) from the cardiovascular literature would be especially precious to me. Best regards, -Cody Hamilton [[alternative HTML version deleted]]

Edwards Lifesciences (NYSE: EW) is a global leader in products and technologies to treat advanced cardiovascular disease, the global leader in acute hemodynamic monitoring and the number-one heart valve company in the world. Headquartered in Irvine, California, Edwards has more than 5,000 employees worldwide, selling medical technologies in more than 100 countries. Edwards Lifesciences leverages its research,...

Statistical Programmer (SAS or Splus/R) About the Company: Edwards Lifesciences (NYSE: EW) is a global leader in products and technologies to treat advanced cardiovascular disease, the global leader in acute hemodynamic monitoring and the number-one heart valve company in the world. Headquartered in Irvine, California, Edwards has more than 5,000 employees'' worldwide, selling medical technologies in more than 100 countries. Edwards Lifesciences leverages i...

Thanks Andris, Michael and Petr for your prompt and kind feedbacks. I will try generating my own biplot from low-level graph commands... I hope it will work. Best regards, Marco -- Marco Manca, MD University of Maastricht Faculty of Health, Medicine and Life Sciences (FHML) Cardiovascular Research Institute (CARIM) PO Box 616 6200 MD Maastricht E-mail: m.manca at path.unimaas.nl Office telephone: +31(0)433874633 Personal mobile: +31(0)626441205 Twitter: @markomanka ********************************************************************************************************************...

...east one panel Also When I try to use the auPred() function I get the follwoing error msg: >plot(augPred(Lac.lme)) Error in tapply(as.character(object[[nm]]), groups, FUN[[dClass]]) : arguments must have same length Any suggestions? Thanks -- Osman O. Al-Radi, MD, MSc, FRCSC Fellow, Cardiovascular Surgery The Hospital for Sick Children University of Toronto, Canada

...;numeric" in the call to model.response, but it does not change anything for me. How do I retrieve the response from a formula without loosing its "ts" status? Best, Claus ---------------------------------------------------- Claus Dethlefsen, MSc, PhD Biostatistician at Center for Cardiovascular Research Aalborg Hospital, Aarhus University Hospital, Denmark

About the Company: Edwards Lifesciences (NYSE: EW) is a global leader in products and technologies to treat advanced cardiovascular disease, the global leader in acute hemodynamic monitoring and the number-one heart valve company in the world. Headquartered in Irvine, California, Edwards has more than 5,000 employees worldwide, selling medical technologies in more than 100 countries. Edwards Lifesciences leverages its researc...

...3 NA 3 7 4 4 4 8 5 5 5 9 6 6 NA In reality I have multiple data frames with numerous columns, all with this problem. I can do the merge seamlessly in SAS, but am trying to learn and stick with R for my analyses. Any help would be greatly appreciated. Steve Lubitz Cardiovascular Research Fellow, Brigham and Women's Hospital and Massachusetts General Hospital

...ng group which consist of two PhD students and two post-doctoral research fellows. 2) evaluate the "operational" efficacy of drugs that have been identified to produce QTc-interval prolongation in early clinical development. The translational research working group will focus on cardiovascular safety, schizophrenia and neuropathic pain. This working group consists in total of six PhD students and two post-doctoral fellows. Requirements ________________________________________ The post-doctoral fellows should have the following background and competencies: * A strong b...

Post-Doctoral Fellowship Modelling of Cardiovascular Safety (full time) Leiden University, Leiden, The Netherlands <javascript:doredirect();> Job description TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PKPD modelling platform. This platform focuses on the transfer of knowledge from academia to...

...aller_1.4.9 DBI_0.2-5 [4] IRanges_1.14.4 preprocessCore_1.18.0 RSQLite_0.11.2 [7] stats4_2.15.2 tools_2.15.2 zlibbioc_1.2.0 Thank you in advance, Marco -- Dr Marco Manca University of Maastricht Faculty of Health, Medicine and Life Sciences (FHML) Cardiovascular Research Institute (CARIM) Mailing address: PO Box 616, 6200 MD Maastricht (The Netherlands) Visiting address: UNS40 West building - 5th floor Room5.544, Universiteit Singel 40, 6229 HX Maastricht E-mail: m.manca at maastrichtuniversity.nl Office telephone: +31(0)433884289 Personal mobile: +31(0...

...have a factor such that lower-order data *must* be on a curve that is offset beneath a higher-order curve. Don't ask where the factors come from...but *given* these factors the assumption, or rather the *constraint*, is that lower orders are better (lower-order rats are fitter rats with better cardiovascular response). Most important is that these curves do not intersect because of these factors (a fitter rat can not have a worse heart-rate response than a less fit rat!). Here's a schematic to show you what I mean. It's very rough, but it gets the point across: seq(0, 1, len=100) f<- 1/se...

...rong computational skills in R, S-plus or SAS * Biological knowledge including more than superficial understanding of cell and molecular biology and genetics. Preferred candidates will have: * Formal training in, or thorough understanding of, human physiology particularly metabolic systems and cardiovascular biology * Additional computing skills in scripting languages, such as perl, python, UNIX shell scripts or others. To Apply: Go to http://pfizer.com/careers/ and choose "Find a Career at Pfizer" on the left and click on "Apply". This position can be found by searching f...