search for: biomarkers

One Year Student in Bioinformatics (Biomarkers discovery)-1000435 See following URL for job application: http://www.merckserono.com/en/careers/job_center/job_center.html Description Background: Biomarker discovery is now an intricate part of the drug development process as it will allow for more accurate identification of patients who...

...tion of metabolites, measurement of their absolute concentrations, and mapping to their respective pathways. We are looking for a PhD holder in Bioinformatics with a minimum of three years working experience to support our biomarker team in the identification, validation and further development of biomarkers. The chosen candidate will be part of our multidisciplinary team conducting studies to discover and develop diagnostic biomarkers, as well as biomarkers for the characterization of disease models and drug effects, including side effects. Essential functions * Analyzing omics data and integration...

Dear all, The CRUK MI have multiple positions in and around bioinformatics, biostatistics and computational biology. These range from HPC and mathematical programming, through biostatistics and biomarkers, to computational biology and bioinformatics. Focuses include single cell genomics and personalised medicine in lung and prostate cancer. For full details, please visit our website at: http://www.cruk.manchester.ac.uk Brief summaries below: RNA Biology Group - Crispin Miller ===================...

Hi, Is there anyone know if BUGS language allows the combination of variables as response such as Y[i] <- a*X1[i]+b*X2[i] Y[i] ~ dnorm(c,d) It seems doesn't work in my model. The problem is between two ######. The error message is > modelCheck("BayesBioMarker.BUGS") model is syntactically correct > modelData(paste("BUGS_data.txt",sep="")) data

Dear R-Helpers, I am a novice in survival analysis. I have the following code: for (i in 3:12) print(coxph(Surv(time, status)~a[,i], data=a)) I used it to fit the Cox Proportional Hazard models separately for every available parameter (columns 3:12) in my data set - with intention to compare the Hazard Ratios. However, some of my variables are in range 0.1 to 1.6, others in range 5000 to

...r AVEO's own clinical stage oncology drug candidates. Responsibilities The candidate will: * Participate in generating, processing and evaluating large oncology-related datasets. * Work on a variety of high-dimensional data projects largely centered on biomarker discovery and develop biomarkers for response to therapy and disease subtype classification * Execute a wide range of computational and analytical tasks, including developing and implementing algorithms for target identification and biomarker discovery. * Integrate publicly or commercially available genomic data with novel experi...

We are looking for a MSc or PhD holder in Bioinformatics,Molecular/Computational Biology or Computer Science to support ourbiomarker team in the identification, validation and furtherdevelopment of biomarkers. The chosen candidate will be part of ourmultidisciplinary team conducting studies to discover and developdiagnostic biomarkers as well as biomarkers for the characterization ofdisease models and drug effects ? including side effects. Essential functions * Analyzing omics data and integration of...

Hey guys, this was sent to the openbsd-misc mailing list tonight. It might be interesting for some people here as well. - Christian ----- Forwarded message from "Alexey E. Suslikov" <cruel@texnika.com.ua> ----- Date: Tue, 11 Jan 2005 11:36:08 +0200 From: "Alexey E. Suslikov" <cruel@texnika.com.ua> Subject: Biometric Authentication for BSD/Linux X-Mailer: The

...dy of injury induced immunosuppression. This program aims at (i) describing and understanding the mechanisms leading to post-injury immune dysfunctions as well as their association with increased risk of health-care associated infections or fatal outcomes, (ii) identifying and developing innovative biomarkers that could help to monitor immunosuppression and stratify patients in clinical trials. Within this structure, a position funded for 2 years (post-doctoral or equivalent) in bioinformatics and biostatistics is open for recruitment. Job Description Bioinformatics to analyze high-throughput datas...

...t NRI or IDI. Can anyone suggest any other packages that can calculate NRI and IDI for survival data? The reference for NRI extending to survival data is: Pencina MJ, D'Agostino RB, Steyerberg EW (2011): Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat in Med 30:11-21 Thanks! John [[alternative HTML version deleted]]

...MS/A or equivalent (at least 4 years relevant experience with demonstrated experience processing data from multiple protocols). Demonstrated ability to communicate ideas and some experience communicating to an audience through various formats. Programmers will support the Statistical Genetics and Biomarkers group in the analysis of genetic, genomic, and biomarker data from clinical trials. We prefer candidates to be proficient in both S-Plus/R and SAS programming, but will consider having one position focused on S-Plus/R and the other on SAS. All candidates should be proficient in programming, modular...

Dear R-helpers, This may sound simple to you, but I'm a beginner in this, so please be forgiving. I have a following problem: two analytes were measured in patient's blood on 4 occasions: ProteinA and ProteinB. How to correctly evaluate correlation between ProteinA and ProteinB? I tried: x <- data.frame(Patient.ID=rep(1:10, each=4), Visit=rep(c(1:4),10), ProteinA=rnorm(m=10,

Dear Sirs. I am working with the R packages Hmisc and PredictABEL to make NRI estimates from my Cox models with and without a specific biomarker. According to Pencina et al (Statistics in Medicine 2010, DOI: 0.1002/sim.4085 ), a continuous/non-categorical NRI (NRI>0) is to be used when there are no obvious reason to categorize risk, such as the risk of future cardiovascular events in patients

Hello, I have made an R script that prepares a NONMEM dataset and I would like to start the NONMEM run right after the dataset is ready. I am using windows XP, R 2.9.1 and NONMEM 6. I have prepared a run.bat file that looks like this: ---------------------------------------- call K:\nmvi\NMdirectories.bat call K:\nmvi\nmfe6 "path\control.txt" "path\output.txt"

Dear R-helpers, I am working with 'cph' models from 'rms' library. When I build simple survival models, based on 'Surv(time, event)', everything is fine and I can make nice plots using plot(Predict(f, time=3)). However, recently I tried to be more specific and used 'Surv(start, stop, event)' type model. Using this model 'plot(Predict(f))' works OK, but

...up participant on Clinical Project teams representing clinical programming efforts for that clinical team. -Prefer candidate with clinical experience. -SAS program experience required. Responsibilities: -Contribute to the programming of tables and graphs for various projects related to genomics/biomarkers and discovery, which include in vitro and animal pharmacology. -Help develop automation tools in Microsoft Excel using internal links to Visual Basic, SAS or R; develop SAS macros and R functions for various analysis tasks, with guidance and core code from the statisticians. -SAS and S-Plus/R pro...

...up participant on Clinical Project teams representing clinical programming efforts for that clinical team. -Prefer candidate with clinical experience. -SAS program experience required. Responsibilities: -Contribute to the programming of tables and graphs for various projects related to genomics/biomarkers and discovery, which include in vitro and animal pharmacology. -Help develop automation tools in Microsoft Excel using internal links to Visual Basic, SAS or R; develop SAS macros and R functions for various analysis tasks, with guidance and core code from the statisticians. -SAS and S-Plus/R pro...

Dear R-helpers and graphics gurus, I have two problems with plotting confidence bands: 1. First is relatively simple. I am using the Passing-Bablok procedure to obtain "unbiased" regression coefficients. This procedure yields the "a" & "b" coefficient values along with their confidence intervals. I then plot the raw data with the regression line, but I would

Dear R-Helpers, I'm working with immunoassay data and 5PL logistic model. I wanted to experiment with different forms of weighting and parameter selection, which is not possible in instrument software, so I turned to R. I am using R 2.14.2 under Win7 64bit, and the 'nls' library to fit the model - I started with the same model and weighting type (1/y) as in the instrument to see

Dear All, I know how to export graphics as pdf files and then how to include them in LaTeX documents. However, I do not know how to do in order to have the text of the graphics written with the font selected for the LaTeX document. Is that possible? Thanks in advance, Paul