R sig jobs - Jun 2015 - Post-doc in Systems Genetics, Gagneur lab, Munich

Dear all,

we seek a talented and motivated post-doc to develop computational methods for
inferring the molecular basis of genetic diseases by integration of personal
omics data. Research topics include: identifying causal mutations of rare
disease patients by meta-analysis; inferring disease-causing molecular pathways
from genotype, phenotypes, and omics profile of patient-derived cell lines
(transcritptomic, proteomic and metabolic). The developed methods will be
applied to data from our collaborator Dr. Holger Prokisch, Institute of Human
Genetics of Munich (cellular respiratory disorders) and will lead to functional
validation studies directly on cell lines derived from patients.

The successful candidate will be part of SOUND, an international research
project funded by the European Commission within its Horizon 2020 Research and
Innovation programme ?Personalizing Health and Care?. Its objective is to create
the bioinformatic tools for statistically informed use of personal genomic and
other ?omic data in medicine, including cancers and rare metabolic diseases. It
comprises partners from top research institutions including Cambridge, Munich,
Zurich, Seattle, Heidelberg and Lisbon, and will run from September 2015 for 3
years.

Candidates must either hold a PhD in computational biology or bioinformatics, or
hold a PhD in physics, statistics, or applied mathematics with practical
experience with high-dimensional data analysis. Experience in quantitative
genetics is a plus. Applicants must have a proven publication record and an
interest for translational research.

The Gagneur lab is a young, lively, and multidisciplinary group with a research
focus on systems genetics and gene regulation. It is located at the Gene Center
of the LMU (University of Munich), an interdisciplinary institution whose 16
independent research groups investigate the regulation of gene expression at all
levels - from the underlying molecular mechanisms to the biological system. The
institute is located on the biomedical research campus Munich-Grosshadern,
offering a dynamic, interactive and internationally oriented research
environment. The dynamism of Munich and the proximity of the Alps provide an
excellent quality of life.

The salary is according to the TV-L (German academic salary scale).

Applications including a cover letter, CV, and references must be sent to Julien
Gagneur (gagneur at genzentrum.lmu.de) until July 31st 2015

http://www.gagneur.genzentrum.lmu.de

Relevant references:
Gagneur et al., PLoS Genetics, 2013, Genotype-Environment Interactions Reveal
Causal Pathways That Mediate Genetic Effects on Phenotype
Kornblum et al, Nature Genetics, 2013, Loss-of-function mutations in MGME1
impair mtDNA replication and cause multisystemic mitochondrial disease
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