Often, these will report an error loading one of their DLLs, usually a sequencer dll of some sort. This is due to thunking! Win9* MIDI works on 16 bits. This problem can be corrected by running WINE as nt4. Winxp will usually not work. One set to nt4, I had the following results: Onyx and related software: Runs afoul of the registration. The one which reported time left to evaluate came up with its own error-reporting box. WINE reported problems with a "stub" Jammer Pro 5: Comes up. Only the "midimapper" is reported as a device and this does not work. File open boxes do not paint correctly and do not find all their files. I believe that both of these use Microsoft Visual Studio. Non-functioning MIDI is a common problem in WINE, it seems, though I have some applications work perfectly but those only using OSS.