similar to: Coxph frailty model counting process error X matrix deemed singular

I am trying to build a model to aid a clinical decision. Certain patients have a blood marker measured at each visit - a rise of this may indicate recurrence of the cancer after treatment (endpoint is "clinical recurrence", censored). In a proportion (up to 30%), this rise is a false positive - hence I wish to correlate factors at the time of the rising test to clinical recurrence,

Hello, I was hoping that someone could answer a few questions for me (the background is given below): 1) Can the coxph accept an interaction between a covariate and a frailty term 2) If so, is it possible to a) test the model in which the covariate and the frailty appear as main terms using the penalized likelihood (for gaussian/t frailties) b)augment model 1) by stratifying on the variable that

Dear List, In documents (Therneau, 2003 : On mixed-effect cox models, ...), as far as I came to know, coxme penalize the partial likelihood (Ripatti, Palmgren, 2000) where as frailtyPenal (in frailtypack package) uses the penalized the full likelihood approach (Rondeau et al, 2003). How, then, coxme and coxph(...frailty(id, dist='gauss')) differs? Just the coding algorithm, or in

Dear R users: I'm generating the following survival data: set.seed(123) n=200 #sample size x=rbinom(n,size=1,prob=.5) #binomial treatment v=rgamma(n,shape=1,scale=1) #gamma frailty w=rweibull(n,shape=1,scale=1) #Weibull deviates b=-log(2) #treatment's slope t=exp( -x*b -log(v) + log(w) ) #failure times c=rep(1,n) #uncensored indicator id=seq(1:n) #individual frailty indicator

Dear all, Does the frailty.object$history[[1]]$theta returns the Variance of random effect? Why is the value different? Here is an example with kidney data: > library(survival) > data(kidney) > frailty.object<-coxph(Surv(time, status)~ age + sex + disease + frailty(id), kidney) > frailty.object Call: coxph(formula = Surv(time, status) ~ age + sex + disease + frailty(id), data

Hi: I have a few clarification questions about the elements returned by the coxph function used in conjuction with a frailty term. I create the following group variable: group <- NULL group[id<50] <- 1 group[id>=50 & id<100] <- 2 group[id>=100 & id<150] <- 3 group[id>=150 & id<200] <- 4 group[id>=200 & id<250] <- 5 group[id>=250

Dear List, Can anyone please explain the difference between cluster() and frailty() in a coxph? I am a bit puzzled about it. Would appreciate any useful reference or direction. cheers, Ehsan > marginal.model <- coxph(Surv(time, status) ~ rx + cluster(litter), rats) > frailty.model <- coxph(Surv(time, status) ~ rx + frailty(litter), rats) > marginal.model Call: coxph(formula =

Does someone know the rules by which 'coxph' returns 'frail', the predicted frailty terms? In my test function: ----------------------------------------------- fr <- function(){ #testing(frailty terms in 'survival' require(survival) dat <- data.frame(exit = 1:6, event = rep(1, 6), x = rep(c(0, 1), 3),

Dear all, I have been doing some frailty calculations and been facing some difficulties. I can extract coefficients, value of theta and the following things library(survival) fit<-coxph(Surv(time,status)~covariate+frailty(group), data=simulated.data) fit$coef fit$history[[1]]$theta fit$history[[1]]$c.loglik fit$var fit$var2 from a frailty included coxph object: but how can i know what other

Dear R members, I am new in using frailty models in survival analyses and am getting some contrasting results when I compare the Wald and likelihood ratio tests provided by the r output. I am testing the survivorship of different sunflower interspecific crosses using cytoplasm (Cyt), Pollen and the interaction Cyt*Pollen as fixed effects, and sub-block as a random effect. I stratified

Hello, I am working on the frailty model using coxph functions. I am running some simulations and want to store the variance of frailty (theta) values from each simulation result. Can anyone help me how to extract the theta values from the results. I appreciate any help. Thanks Shankar Viswanathan

Dear all, this is probably a very silly question, but could anyone tell me what the different parameters in a coxph model with a frailty.gamma term mean? Specifically I have two questions: (1) Compared to a "normal" coxph model, it seems that I obtain two standard errors [se(coef) and se2]. What is the difference between those? (2) Again compared to a "normal" coxph model,

Dear all, I have a data set<http://yaap.it/paste/c11b9fdcfd68d02b#gIVtLrrme3MaiQd9hHy1zcTjRq7VsVQ8eAZ2fol1lUc=>with 6 clusters, each containing 48 (possibly censored, in which case "event = 0") survival times. The "x" column contains a binary explanatory variable. I try to describe that data with a gamma frailty model as follows: library(survival) mod <-

Hi, I have a question about the output for variance of random effect from a gamma frailty model using coxph in R. Is it the vairance of frailties themselves or variance of log frailties? Thanks. Guanghui

I would like to plot a survival curves of a group with different categories after running a Cox model with frailty() random effects terms. I just could display a survival plot of the covariable?s mean. Here an example: library(survival) fit<-coxph(Surv(time, status) ~ sex+ frailty(litter, dist='gamma', method='em'), rats) summary(fit ) suf<-survfit(fit) plot(suf,

Dear all, I have a question with respect to counting process formulation of the coxph(survival) model. I have two groups of observations for which I have partitioned each observation into two distinct time intervals, namely, entry day till day 13, and day 13 till death or censorship day (of course the latter only for the observations that survived the first 13 day interval), and added a

Dear List, How do I extract the approximate Wald test for the frailty (in the following example 17.89 value)? What about the P-values, other Chisq, DF, se(coef) and se2? How can they be extracted? ######################################################> kfitm1 Call: coxph(formula = Surv(time, status) ~ age + sex + disease + frailty(id, dist = "gauss"), data = kidney)

Dear R users, I'm trying to fit a gamma-frailty model on a simulated dataset, with 6 covariates, and I'm running into some results I do not understand. I constructed an example from my simulation code, where I fit a coxph model without frailty (M1) and with frailty (M2) on a number of data samples with a varying degree of heterogeneity (I'm running R 2.3.1, running takes ~1 min).

I'm trying to estimate a cox proportional hazards regression for repeated events (in gap time) with time varying covariates. The dataset consists of just around 6000 observations (lines) (110 events). The (stylized) data look as follows: unit dur0 dur1 eventn event ongoing x 1 0 1 0 0 0 32.23 1 1 2 0 1 1 35.34 1

Hi R-users I spend a lot of time searching on the web but I didn?t found a clear answer. I have some doubts with 'frailty' function of 'survival' package. The following model with the function R ?coxph? was fitted: modx <- coxph(Surv(to_stroke, stroke) ~ age + sbp + dbp + sex + frailty(center,distribution = "gamma", method='aic'), data=datax) Then I get