similar to: Pharmacokinetic and pharmacodynamic modeling and simulation

Displaying 20 results from an estimated 500 matches similar to: "Pharmacokinetic and pharmacodynamic modeling and simulation"

2007 Mar 23
0
course on Analysis of Repeated Measurements by Ronald Geskus
Analysis of Repeated Measurements By Dr. Ronald Geskus April 27, 2007 Amsterdam, The Netherlands http://www.can.nl/events/details.php?id=31 This course is aimed at everyone who is working with data that contain repeated measurements on persons or otherwise related data and who wants to analyse such data in a proper way. In many situations one may have data that show some
2008 Mar 28
0
Vacancy Principal Postdoc PK-PD modeling The Netherlands
________________________________ Principal Post-Doctoral Fellow PKPD modelling platform (full time) Leiden University, Leiden, The Netherlands <javascript:doredirect();> Job description ________________________________ TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PK-PD modelling platform. This platform focuses on the transfer of
2008 Mar 28
0
Vacancy Post Doc PK-PD modeling the Netherlands
Post-Doctoral Fellowship Modelling of Cardiovascular Safety (full time) Leiden University, Leiden, The Netherlands <javascript:doredirect();> Job description TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PKPD modelling platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a
2009 Sep 30
1
pam_authenticate() failed
Hi List, I have a problem with auth for just one user: dovecot: Sep 30 09:56:16 Info: auth(default): new auth connection: pid=3809 dovecot: Sep 30 09:56:17 Info: auth(default): client in: AUTH 1 PLAIN service=IMAP secured lip=127.0.0.1 rip=127.0.0.1 resp=AGoucnVpc0BtZXJreC12ZXJrZXJrLm5sAGJsb2VtMDEh dovecot: Sep 30 09:56:17 Info: auth(default): pam(j.ruis at
2006 May 04
0
Online course- Mixed Effects Models
Dr. Andrzej Galecki will present his online course "Mixed Effects Models with Applications" May 12 ? June 9 at statistics.com. This course will explain the basic theory of linear and non-linear mixed effects models, including hierarchical linear models (HLM). It will outline the algorithms used for estimation, primarily for models involving normally distributed errors, and will provide
2010 May 06
0
Release of the scaRabee package
Dear R-users, I am pleased to announce the release of scaRabee, a new R package which constitutes a toolkit for modeling and simulation in the field of pharmacometrics. It was designed as a user-friendly interface to create and modify model scripts, define system observations and inputs, and run simulation or estimation analysis. scaRabee provides templates for the definition of
2010 May 06
0
Release of the scaRabee package
Dear R-users, I am pleased to announce the release of scaRabee, a new R package which constitutes a toolkit for modeling and simulation in the field of pharmacometrics. It was designed as a user-friendly interface to create and modify model scripts, define system observations and inputs, and run simulation or estimation analysis. scaRabee provides templates for the definition of
2015 Mar 17
0
Postdoc in Pharmacometrics at the University of Cape Town
Dear all, at the Division of Clinical Pharmacology at the University of Cape Town (South Africa) we are looking for highly motivated science/engineering PhD graduates to join our pharmacometrics group as a post-doctoral fellow. Pharmacometrics is an emerging discipline that applies mathematical modelling and simulation to pharmacology, aiding the interpretation of data from clinical trials,
2009 Jul 20
0
Vacancy - PhD / Post-doctoral position at the University of Leiden.
TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PKPD modelling platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a collaborative effort of four excellent academic institutes and six leading global pharmaceutical industries. Unique to this platform is the availability of shared databases on
2008 Nov 10
0
Postdoc Positions Available at Leiden University The Netherlands
Two Postdoctoral fellows (fulltime) Leiden University, Leiden, The Netherlands Job description ________________________________________ TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PK-PD modelling platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a collaborative effort of
2011 Jul 06
1
question about getting things out of an lapply
Dear R-help subscribers, I have a quite stupid question about using lapply. I have the following function: create.gradient <- function(i){ colorgrad01<-color.scale(seq(0,1,by=0.01), extremes=c("red","blue")) tree1$edge[i,1] -> x tree1$edge[i,2] -> y print(x) print(y) all2[x] -> z all2[y] -> z2 round(z, digits = 2) -> z round(z2, digits = 2) -> z2
2011 Jul 06
1
gradient generation
Dear R-help subscribers; I have a question regarding making gradients in R. I've searched on the web, but was only able to find functions that make a gradient between color X and Y, which is not what I want. I want to 'pick out' individual, smaller pieces of a gradient based on a range of numbers. Say that I have a range of numbers, leading from 0 to 1. Then I want 0 to refer to
2011 Jul 04
1
placing multiple rows in a single row
Dear people from the R help list, I have a question that I can't get my head around to start answering, that is why I am writing to the list. I have data in a format like this (tabs might look weird): John A1 1 0 1 John A2 1 1 1 John A3 1 0 0 Mary A1 1 0 1 Mary A2 0 0 1 Mary A3 1 1 0 Peter A1 1
2004 Sep 18
0
Pharmacokinetics using R
Hi, I just wonder if R is still used for PK analysis. However, I have to use R for some purposes anyways. Here is a really strange problem I am running into and I hope to get some assistance from the group. The following code works fine in S-Plus (Population estimates and MAP estimates look reasonable ). cs.fit<-nlme ( CONC~phenoModel(CID,TIME, DOSE, lCl, lV), fixed = lCl+lV ~1,
2011 Sep 05
0
saemix: SAEM algorithm for parameter estimation in non-linear mixed-effect models (version 0.96)
saemix implements the SAEM (stochastic approximation EM) algorithm for parameter estimation in non-linear mixed effect models, used to model longitudinal data. Longitudinal data are particularly prominent in pharmacokinetics (study of drug concentrations versus time) and pharmacodynamics (study of drug effect versus time), but the SAEM algorithm has also been successfully applied in many
2011 Sep 05
0
saemix: SAEM algorithm for parameter estimation in non-linear mixed-effect models (version 0.96)
saemix implements the SAEM (stochastic approximation EM) algorithm for parameter estimation in non-linear mixed effect models, used to model longitudinal data. Longitudinal data are particularly prominent in pharmacokinetics (study of drug concentrations versus time) and pharmacodynamics (study of drug effect versus time), but the SAEM algorithm has also been successfully applied in many
2019 Jan 25
0
PhD student and postdoc positions in pharmacometrics at the University of Cape Town
Dear all, We are looking for bright and motivated candidates to join our pharmacometric modelling team at the University of Cape Town. Pharmacometrics is an emerging discipline that uses mathematical and statistical tools to quantify drug, disease, and trial information to aid efficient drug development and/or regulatory decisions. It designs and applies mathematical models to describe the
2009 Jan 28
3
mount.cifs is not working (smbclient does work), somekind of recursive content in mount-dir
Hi all, When I try to make a connection to our windows server with smbclient: smbclient //server/dira/dirb/dirc -U username -W workgroup Password: ***** I get a working ftp-like connection to our data. When I try to make the same connection with mount.cifs: mount.cifs //server/dira/dirb/dirc /mnt/mnt_dir -o user=877790 dom=workgroup Password: ***** I get a mount to a location which appears
2008 Jul 03
3
Re membering the last time an event occurred within a dataframe
All, I am constructing a pharmacokinetic dataset and have hit a snag. The dataset can be demonstrated in the following way: myData <- data.frame( evid = c(1, 0, 0, 0, 1, 0, 1, 1, 1, 0), time = 1:10, last.dose.time = c(1, 1, 1, 1, 5, 5, 7, 8, 9, 9) ) The evid field is an indicator variable for whether the associated observation is a dosing record (when it takes value 1) or an
2006 Apr 20
2
nlminb( ) : one compartment open PK model
All, I have been able to successfully use the optim( ) function with "L-BFGS-B" to find reasonable parameters for a one-compartment open pharmacokinetic model. My loss function in this case was squared error, and I made no assumptions about the distribution of the plasma values. The model appeared to fit pretty well. Out of curiosity, I decided to try to use nlminb( ) applied to a