similar to: nested model: lme, aov and LSMeans

Hi, There are 20 subjects grouped by Gender, each subject has 2 tissues (normal vs. cancer). In fact, it is a 2-way anova (factors: Gender and tissue) with tissue nested in subject. I've tried the following: Model 1: lme(response ~ tissue*Gender, random = ~1|subject) Model 2: response ~ tissue*Gender + subject Model 3: response ~ tissue*Gender It seems like Model 1 is the correct one

Dear all, I would like to know if it is possible to fit in R a Cox ph model with time-dependent covariates and to account for hierarchical effects at the same time. Additionally, I'd like also to know if it would be possible to perform any feature selection on this model fit. I have a data set that is composed by multiple marker measurements (and hundreds of covariates) at different time

Hello, I've used this command to analyse changes in brain volume: mod1<-aov(Volume~Sex*Lobe*Tissue+Error(Subject/(Lobe*Tissue)),data.vslt) I'm comparing males/females. For every subject I have 8 volume measurements (4 different brain lobes and 2 different tissues (grey/white matter)). As aov() provides only type I anovas, I would like to use lmer() with type II, however, I have

Hi, I am doing an analysis to see if these is tissue specific effects on the gene expression data . Our data were collected from 6 different labs (batch effects). lab 1 has tissue type 1 and tissue type 2, lab 2 has tissue 3, 4,5,6. The other labs has one tissue type each. The 'sample' data is as below:

Hello, I'm using aov() to analyse changes in brain volume between males and females. For every subject (there are 331 in total) I have 8 volume measurements (4 different brain lobes and 2 different tissues (grey/white matter)). The data looks like this: Subject Sex Lobe Tissue Volume subect1 1 F g 262374 subect1 1 F w 173758 subect1 1 O g 67155 subect1 1 O w 30067 subect1 1 P g 117981

Dear all I apologize for cross-posting, but first it is accepted custom to thank the repliers and give a summary, and second I have still the feeling that this problem might be a general statistical problem and not necessarily related to microarrays only, but I might be wrong. First, I want to thank Robert Gentleman, Mark Kimpel and Mark Reiners for their kind replies. Robert Gentleman kindly

Dear Dr. Bates, and R-help, I've tried the anova function to test the difference between two coefficients, as shown on page 225 of your book "Mixed Effects Models in S and S-Plus (Statistics and Computing)". When I type: anova( fm2BW.lme, L = c(TimeDiet2 = 1, TimeDiet3 = -1) ) I got the following error message: Error: unexpected '=' in "anova( fm2BW.lme, L =

Dear R users, I have a data frame in the form below, on which I would like to make normality tests on the values in the ExpressionLevel column. > head(df) ID Plant Tissue Gene ExpressionLevel 1 1 p1 t1 g1 366.53 2 2 p1 t1 g2 0.57 3 3 p1 t1 g3 11.81 4 4 p1 t2 g1 498.43 5 5 p1 t2 g2 2.14 6 6 p1 t2 g3 7.85 I

My small brain is having trouble getting to grips with lme() I wonder if anyone can help me correctly set the random = argument to lme() for this kind of setup with (I think) 9 variance/covariance components ... Study.1 Study.2 ... Study.10 Treatment.A: subject: 1 2 3 4 5 6 etc. 28 29 30 Treatment.B: subject: 31

dear members, i would like to write a variable in a plot title (main="") but i don't know the right syntax:(...i tried a lot of different ways without success. here my example: y=30 z=33 for (i in 10:length(tissue)) { png(filename = tissues[i], width = 1024, height = 768, pointsize = 12, bg = "white") gene.graph("ENSG00000115252", rma.affy, gps=list(1:3,

Hi Dear all, I have some gene expression data samples from different tissue types ----------------------------------------------- - 120 samples from blood (B) - 20 samples from Liver (L) - 15 samples from Kidney (K) - 6 samples from heart (H) ----------------------------------------------- All the samples are from different individuals, so there are in total 161 individuals from which the DNA was

Hi, I've lost my mind on it... I have to scatterplot two vectors, grouped by a third variable, with two different dimensions according to whether each cell line in the plot is sensitive or resistant to a given drug, and with a different color for each of 9 tissues of origin. Here's what I've done:

Dear fellow R-help members, I hope to seek your advice on how to parse/manage a dataset with hundreds of columns. Two examples of these columns, 'cancer.problems', and 'neuro.problems' are depicted below. Essentially, I need to parse this into a useful dataset, and unfortunately, I am not familiar with perl or any such language. data <- data.frame(id=c(1:10))

Dear R users, I have a huge database and I need to adjust it somewhat. Here is a very little cut out from database: CODE NAME DATE DATA1 4813 ADVANCED TELECOM 1987 0.013 3845 ADVANCED THERAPEUTIC SYS LTD 1987 10.1 3845 ADVANCED THERAPEUTIC SYS LTD 1989 2.463 3845 ADVANCED THERAPEUTIC SYS LTD 1988 1.563 2836 ADVANCED TISSUE

Dear R users, I have trouble obtaining the same results for nested Anova with two fixed factors when using lm and aov functions. The formulas are: > e1=aov(y~x/z) > e2=lm(y~x/z) summary(e1) Df Sum Sq Mean Sq F value Pr(>F) x 47 260.0 5.5 18.0088 < 2.2e-16 *** x:z 195 169.6 0.9 2.8318 < 2.2e-16 *** Residuals 14425

Hi, I have a question about how to do covariate adjustment. I have two sets of 'gene expression' data. They are from two different tissue types, 'liver' and 'brain', respectively. The purpose of my analysis is to compare the pattern of the whole genome 'gene expression' between the two tissue types. I have 'age' and 'sex' as covariates. Since

Hi, Thanks in advance for any advice you can give me, I am very stumped on this problem... I use R every day and consider myself a confident user, but this seems to be an elementary problem.. Outline of problem: I am analysing the results of a study on protein expression in cancer tissues. I have raw intensities from 2 different types of cancer and normal tissue, which can be taken from several

I am trying to sample a subset from a matrix using sample. The size of the matrix is 20X 1532. It works fine with this, but when I transpose the matrix and try to sample it, it returns null. pick.set<-sample(tissue.exp.t,5,replace=FALSE,prob=NULL) Is there something that I am missing here ? Thanks ../Murli

Dear useRs, Am trying to use xtable on the following data.frame and I don't get what I expect: example.table <- data.frame(rbind( c("Gender"," "," "," "), cbind(rep(" ",2),c("Male","Female"),c(3.0,4.0),c(3/7,4/7)) )) colnames(example.table) <- c(" "," ","number of

Hello, Excuse me for posting two questions in one day, but I figured it would be better to ask my questions in separate emails. I will again give the caveat that I'm not a statistician by training, but have a fairly decent understanding of probability and likelihood. As before, I'm trying to fit a nonlinear model to a dataset which has two main factors using nlme. Within the dataset