similar to: problem with the assignment function

Hello, I have a large data set 320.000 rows and 1000 columns. All the data has the values 0,1,2. I wrote a script to remove all the rows with more than 46 missing values. This works perfect on a smaller dataset. But the problem arises when I try to run it on the larger data set I get an error “cannot allocate vector size 1240 kb”. I’ve searched through previous posts and found out that it might

Hi, I cant understand where I am going wrong.Below is my code.I would really appreciate your help. Thanks. > genfile<-read.table("c:/tina/phd/bs871/hw/genfile.txt",skip=1) > > #read in SNP data > snp.dat <- as.matrix(genfile) > snp.name <- scan("c:/tina/phd/bs871/hw/genfile.txt",nline=1,what="character") Read 100 items

I have a 2 x 3 matrix called snp and I want to compute the following probability: choose(sum(snp[,1]), snp[1,1]) * choose(sum(snp[,2]), snp[1,2]) * choose(sum(snp[,3]), snp[1,3])/choose(sum(snp), sum(snp[1,])) but I keep getting Infs and NaNs. Is there a function that can do this in R? -- Thanks, Jim. [[alternative HTML version deleted]]

Hi, I'm trying to melt() some data for subsequent cast()ing and am encoutering errors. The overall process requires a couple of casts()s and melt()s. ########Start Session 1########## ## I have the data in a (fully) melted format and can cast it fine... > norm1[1:10,] Pool SNP Sample.Name variable value 1 1 rs1045485 CA0092 Height.1 0.003488853 2 1 rs1045485

Hi I listened to all your advise and ran my data on a computer with a 64 bits procesor but i still get the same error saying "it cannot allocate a vector of that size 1240 kb" . I don't want to cut my data in smaller pieces because we are looking at interaction. So are there any other options for me to try out or should i wait for the development of more advanced computers!

Hi, I am new to R. and even though I've made my code to run and do what it needs to . It is taking forever and I can't use it like this. I was wondering if you could help me find ways to fix the code to run faster. Here are my codes.. the data set is a bunch of 0s and 1s in a data.frame. What I am doing is this. I pick a column and make up a new column Y with values associated with that

Dear All, I have a large data frame with 10 rows and 82 columns. I want to apply the same function to all of the columns with a single command. e.g. zl <- lm (snp$a_109909 ~ snp$lat) will fit a linear model to the values in lat and a_109909. What I want to do is fit linear models for the values in each column against lat. I tried doing zl <- (snp[,2:82] ~ snp$lat[,1]) but got the following

Dear R colleagues, I annotated a list of single nuclotide polymorphiosms (SNP) with the corresponding genes using biomaRt. The result is the following data.frame (pasted from R): snp ensembl_gene_id 1 rs8032583 2 rs1071600 ENSG00000101605 3 rs13406898 ENSG00000167165 4 rs7030479

Hi, I am trying to match the order of the rownames of a dataframe with the rownames of another dataframe (I can't simply sort both sets because I would have to change the order of many other connected datasets if I did that): Also, the second dataset (snp.matrix$fam) is a snp matrix slot: so for example: data_one: x y

Hi, Following my earlier posts about having problems performing a PCA, I have worked out what the problem is. The problem lies within the PLINK to gds conversion. It seems as though the SNPs are imported as "samples" and in turn, the samples are recognised as SNPs: >snpsgdsSummary("chr2L") Some values of snp.position are invalid (should be > 0)! Some values of

Hi Abby, Thanks for getting back to me, yes I believe I did that by doing this: SNP$density <- get_density(SNP$mean, SNP$var) > summary(SNP$density) Min. 1st Qu. Median Mean 3rd Qu. Max. 0 383 696 738 1170 1789 where get_density() is function from here: https://slowkow.com/notes/ggplot2-color-by-density/ and keep only entries with density > 400

Dear All, The following code extracts from NCBI very nice output for ONE allele of a SNP (often the allele with the second largest frequency - usually termed the minor allele). It gives an average minor allele frequency from all NCBI sources (which is what I want, except I'd like the addition of data for all the other alleles of one SNP) plus a table of minor allele frequencies from each

Hi, I'm trying to cast() some data, but keep on getting the following error... > norm.all.melted.height <- transform(all.melted.height, + norm.height = value / ave(value, SNP, Pool, FUN = max) + ) Warning messages: 1: In FUN(X[[147L]], ...) : no non-missing arguments to max; returning -Inf 2: In FUN(X[[147L]],

Hi, My query is regarding permutation test and reshuffling of genotype/phenotype data I have been using the haplo.stats package of R. for haplotype analysis and I would like to perform an analysis which I'm requesting your advice. I have a data set of individuals genotyped for 12 SNP and a dichotomous phenotype. At first, I have tested each of those SNP independently in order to bypass

Hi, I have a list p with different size dataframes and length of over 8000. I'm trying to calculate correlations between the rows of dataframes of this list and columns of another dataset (type data.frame also) so that first column is correlated with all the rows in the list dataframe. Some information from another dataset is also included to the final output (all.corrs). This worked a

Dear All, I am trying to calculate the Hardy-Weinberg Equilibrium p-value for 42 SNPs. I am using the function HWE.exact from the package "genetics". In order not to do a lot of coding "by hand", I have a for loop that goes through each column (each column is one SNP) and gives me the p.value for HWE.exact. Unfortunately some SNP have reached fixation and HWE.exact requires a

If I run an analysis which generates statistical tests on many SNPs I would naturally want to get more details on the most significant SNPs. Directly from within R one can get the information by loading RSNPer (from Bioconductor) and simply issuing a command SNPinfo(2073285). Unfortunately, the command cannot handle a vector and therefore only wants to do one at a time. I tried the lapply and

Hi Guys I have two data frames which I would like to merge on two conditions. I am doing the following (abstract form) new.data.frame <- merge(df1,df2, by=c("Col1","Col2")) It is giving me a null result. Basically I need to apply two conditions. I also tried sqldf but it is running forever. Will indexing help ? temp <- sqldf("select

Hi, I'm using R for a QTL analysis of SNP data. I was wondering if anyone had any advice on fitting a dominance effect into the following function; > myfun4 function (x) { x <- scan(con, nmax=169) y <- unique(x[which(!is.na(x))]) if(length(y)>1) { summary(lme(Ad ~ x, random= ~1|sire, na.action="na.omit")) } else {print("no.infomation")} } Con is the

Hi, I have a vector with elements rs.id=c(''rs100'',''rs101'',''rs102'',''rs103'') And a dataframe ''snp.id'' 1 SNP_100 rs100 2 SNP_101 rs101 3 SNP_102 rs102 4 SNP_103 rs103 Task is to replace