similar to: survit function and cox model with frailty

Hi: I have a few clarification questions about the elements returned by the coxph function used in conjuction with a frailty term. I create the following group variable: group <- NULL group[id<50] <- 1 group[id>=50 & id<100] <- 2 group[id>=100 & id<150] <- 3 group[id>=150 & id<200] <- 4 group[id>=200 & id<250] <- 5 group[id>=250

Dear R users: I'm generating the following survival data: set.seed(123) n=200 #sample size x=rbinom(n,size=1,prob=.5) #binomial treatment v=rgamma(n,shape=1,scale=1) #gamma frailty w=rweibull(n,shape=1,scale=1) #Weibull deviates b=-log(2) #treatment's slope t=exp( -x*b -log(v) + log(w) ) #failure times c=rep(1,n) #uncensored indicator id=seq(1:n) #individual frailty indicator

Dear List, In documents (Therneau, 2003 : On mixed-effect cox models, ...), as far as I came to know, coxme penalize the partial likelihood (Ripatti, Palmgren, 2000) where as frailtyPenal (in frailtypack package) uses the penalized the full likelihood approach (Rondeau et al, 2003). How, then, coxme and coxph(...frailty(id, dist='gauss')) differs? Just the coding algorithm, or in

Does someone know the rules by which 'coxph' returns 'frail', the predicted frailty terms? In my test function: ----------------------------------------------- fr <- function(){ #testing(frailty terms in 'survival' require(survival) dat <- data.frame(exit = 1:6, event = rep(1, 6), x = rep(c(0, 1), 3),

Dear List, Can anyone please explain the difference between cluster() and frailty() in a coxph? I am a bit puzzled about it. Would appreciate any useful reference or direction. cheers, Ehsan > marginal.model <- coxph(Surv(time, status) ~ rx + cluster(litter), rats) > frailty.model <- coxph(Surv(time, status) ~ rx + frailty(litter), rats) > marginal.model Call: coxph(formula =

Dear list, I want o fit a shared gamma frailty model with the frailty specification in the survival package. I have partly left-truncated data and time-dependent covariates. Is it possible to combine these two things in the frailty function. Or are the results wrong if I use data in the start-stop-formulation which account for delayed entry? Is the frailty distribution updated in the

Dear R-users, I have noticed small discrepencies in the reported estimate of the variance of the frailty by the print method for survreg() and the 'theta' component included in the object fit: # Examples in R-2.6.2 for Windows library(survival) # version 2.34-1 (2008-03-31) # discrepancy fit1 <- survreg(Surv(time, status) ~ rx + frailty(litter), rats) fit1 fit1$history[[1]]$theta

Dear R-help, I am trying to estimate a Cox model with nested effects, or better h(t,v,w)=v*w*h0(t)*exp(B'x) where h(t,v,w) is the individual hazard function w and v are both frailty terms (gamma or normal distributed) I have 12 clusters and for each one of them I would like to associate a realization of v, while w is a random effect for the whole population. At the population level

Hello, I am working on the frailty model using coxph functions. I am running some simulations and want to store the variance of frailty (theta) values from each simulation result. Can anyone help me how to extract the theta values from the results. I appreciate any help. Thanks Shankar Viswanathan

Hello, I'm trying to estimate a cox model with a frailty variable and time-dependent covariate (below there is the statement I use and the error message). It's seems to be impossible, because every time I add the time-dependent covariate the model doesn't converge. Instead, if I estimate the same model without the time-dependent covariate it's converge. I'd like knowing if

Hi, I have a question about the output for variance of random effect from a gamma frailty model using coxph in R. Is it the vairance of frailties themselves or variance of log frailties? Thanks. Guanghui

Hola! I started to search for information about multilevel survival models, and found frailty in R. This seems to be something of the same, is it the same? Then: why the name frailty (weekness?) -- Kjetil Halvorsen. Peace is the most effective weapon of mass construction. -- Mahdi Elmandjra

Dear List, How do I extract the approximate Wald test for the frailty (in the following example 17.89 value)? What about the P-values, other Chisq, DF, se(coef) and se2? How can they be extracted? ######################################################> kfitm1 Call: coxph(formula = Surv(time, status) ~ age + sex + disease + frailty(id, dist = "gauss"), data = kidney)

Dear all, I have a data set<http://yaap.it/paste/c11b9fdcfd68d02b#gIVtLrrme3MaiQd9hHy1zcTjRq7VsVQ8eAZ2fol1lUc=>with 6 clusters, each containing 48 (possibly censored, in which case "event = 0") survival times. The "x" column contains a binary explanatory variable. I try to describe that data with a gamma frailty model as follows: library(survival) mod <-

Dear all, this is probably a very silly question, but could anyone tell me what the different parameters in a coxph model with a frailty.gamma term mean? Specifically I have two questions: (1) Compared to a "normal" coxph model, it seems that I obtain two standard errors [se(coef) and se2]. What is the difference between those? (2) Again compared to a "normal" coxph model,

Dear all, This probably stems from my lack of understanding of the model, but I do not understand the variance of the random effect reported in coxme. Consider the following toy example: #------------------------------- BEGINNING OF CODE ------------------------------------------------ library(survival) library(coxme) #--- Generate toy data: d <- data.frame(id = c(1:100), #

Hello, I'm Emanuela, I'm implemented a survival analysis and I'm trying to use a frailty model with inverse gaussian distribution, but I'm not able to find the right code, because it seems to be only a gamma and a gaussian distribution. Is there also the inverse gaussian distribution? Thanks a lot Emanuela Rossi

Hello, I am running R 2.6.1 on windows xp I am trying to fit a cox proportional hazard model with a shared Gaussian frailty term using coxme My model is specified as: nofit1<-coxme(Surv(Age,cen1new)~ Sex+bo2+bo3,random=~1|isl,data=mydat) With x1-x3 being dummy variables, and isl being the community level variable with 4 levels. Does anyone know if there is a way to get the standard error

Dear All, The "coxph" function in the "survival" package allows multiple frailty terms. In all the examples I saw, however, the frailty terms are nested. What will happen if I have non-nested (that is, cross-classified) frailties in the model? Will the model still work? Do I need to take special cares when specifying these models? Thanks! Shige [[alternative HTML

I am confused on how the log-likelihood is calculated in a parametric survival problem with frailty. I see a contradiction in the frailty() help file vs. the source code of frailty.gamma(), frailty.gaussian() and frailty.t(). The function frailty.gaussian() appears to calculate the penalty as the negative log-density of independent Gaussian variables, as one would expect: >