similar to: probit etc. for dose-response modeling

Classification: UNCLASSIFIED Caveats: NONE A similar question has been posted in the past but never answered. My question is this: for probit analysis, how do you program a 95% confidence interval for the LD50 (or LC50, ec50, etc.), including a heterogeneity factor as written about in "Probit Analysis" by Finney(1971)? The heterogeneity factor comes into play through the chi-squared

Hi - I am fitting a probit model using glm(), and the deviance and residual degrees of freedom are different depending on whether I use a binary response vector of length 80 or a two-column matrix response (10 rows) with the number of success and failures in each column. I would think that these would be just two different ways of specifying the same model, but this does not appear to be the case.

Quiero comparar varias dosis letales 50% (LD50) usando análisis probit. He seguido un ejemplo que viene en paquete DRC, pero no obtengo el resultado esperado. Lo que quiero es saber si las LD50s, son diferentes y si la diferencias son estadísticamente significativas. Gracias de antemano. José Arturo e-mail. jafarfan@uady.mx <grejon@uady.mx> e-mail alterno. jafarfan@gmail.com

Hello all, I have a very simple set of data and I would like to analyze them with probit analysis. The data are: X Event Trial 100 8 8 75 8 8 50 6 8 25 4 8 10 2 8 0 0 8 I want to estimate the value of X that will give a 95% hit rate (Event/Trial) and the corresponding 95% CI. Anyone can offer some help? Thanks!! -

Hi All! I am desperately needing some help figuring out how to calculate LD50 with a GLMM (probit link) or, more importantly, the standard error of the LD50. I conducted a cold temperature experiment and am trying to assess after how long 50% of the insects had died (I had 3 different instars (non significant fixed effect) and several different blocks (I did 4 replicates at a time)=

Hi! I was trying to implement a probit model on a dichotomous outcome variable and found that the predictions were outside the (0,1) interval that one should get. I later tried it with some simulated data with a similar result. Here is a toy program I wrote and I cant figure why I should be getting such odd predictions. x1<-rnorm(1000) x2<-rnorm(1000) x3<-rnorm(1000)

Dear R helpers, I need to estimate a probit model with box constraints placed on several of the model parameters. I have the following two questions: 1) How are the standard errors calclulated in glm (family=binomial(link="probit")? I ran a typical probit model using the glm probit link and the nlminb function with my own coding of the loglikehood, separately. As nlminb does not

Hello, First time poster here so let me know if you need any more information. I am trying to run an ordered probit with maximum likelihood model in R with a very simple model (model <- econ3 ~ partyid). Everything looks ok until i try to run the optim() command and that's when I get " Error in rep(1, nrow(x)) : invalid 'times' argument". I had to adapt the code from a 4

 Hello! > I have a very simple set of data and I would like to analyze > them with probit analysis. > The data are: X    Event    Trial > 1210  8        8 > 121  6        8 > 60.5  6        8 > I want to estimate the value of X that will give a 95% hit > rate (Event/Trial) and the corresponding 95% CI. > you can help me? Thanks!! > Trinh  [[alternative HTML version

Folks I have modified an existing function to calculate 'ec/ld/lc' 50 values and their associated Fieller's confidence limits. It is based on EC50.calc (writtien by John Bailer) - but also borrows from the dose.p (MASS) function. My goal was to make the original EC50.calc function flexible with respect to 1) probability at which to calculate the expected dose, and 2) the link

Dear all, I have a very simple set of data and I would like to analyze them with probit analysis. dose event trial 0.0 3 15 1.1 4 15 1.3 4 15 2.0 3 15 2.2 5 15 2.8 4 15 3.7 5 15 3.9 9 15 4.4 8 15 4.8 11 15 5.9 12 15 6.8 13 15 The dose should be transformed with log10(). I use glm(y ~ log10(dose), family=binomial(link=probit)) to do probit analysis, however, I have to exclude the

I have had some weird results using the optim() function. I wrote a probit likelihood and wanted to run it with optim() with simulated data. I did not include a gradient at first and found that optim() would not even iterate using BFGS and would only occasionally work using SANN. I programmed in the gradient and it iterates fine but the estimates it returns are wrong. The simulated data work

Dear all, I have a question on the dose-response estimation with clustered/ correlated binary data. I would like to estimate the hit rate for a certain test at various concentration levels. The test is used on 5 subjects, and each subject is tested 20 times. If we assume that the 100 samples are independent, the hit rate estimate is unbiased, but the variance is under-estimated. The other

Respected Sir/Madam, I have a question regarding calculation of LD50 (Lethal Dose) and IC50 (50% inhibitory concentration) of an antimicrobial experiment. I have used a compound isolated from a plant and observed its effect on the fungus *Fusarium oxysporum* by the food poisoning method. Solutions of the compound at concentrations of 0, 50, 100, 150, 200 and 250µg/ ml were added to

Is there a function to compute the derivative of the probit (qnorm) function in R, or in any of the packages? Thanks, -Andrew [[alternative HTML version deleted]]

Hello, We use drc to fit dose-response curves, recently we discovered that there are quite different standard error values returned for the same dataset depending on the drc-version / R-version that was used (not clear which factor is important) On R 2.9.0 using drc_1.6-3 we get an IC50 of 1.27447 and a standard error on the IC50 of 0.43540 Whereas on R 2.7.0 using drc_1.4-2 the IC50 is

Dear all, I can use the very nice drc package (multdrc()) to model and plot a dataframe containing dose and response values. I can also use predict.drc() to yield response values given a dose. I need to do the opposite, estimate a dose given the response. The general predict documentation seems to say that this is possible, but it does not appear that predict.drc has that capability.

I am working with Probit regression (I cannot switch to logit) can anybody help me in finding out how to obtain with R Finney's fiducial confidence intervals for the levels of the predictor (Dose) needed to produce a proportion of 50% of responses(LD50, ED50 etc.)? If the Pearson chi-square goodness-of-fit test is significant (by default), a heterogeneity factor should be used to calculate

As part of carrying out a complicated maximum likelihood estimation, I am trying to learn to program likelihoods in R. I started with a simple probit model but am unable to get the code to work. Any help or suggestions are most welcome. I give my code below: ************************************ mlogl <- function(mu, y, X) { n <- nrow(X) zeta <- X%*%mu llik <- 0 for (i in 1:n) { if

thanks a lot Renaud. but i was interested in Finney's fiducial confidence intervals of LD50 so to obtain comparable results with SPSS. But your reply leads me to the next question: does anybody know what is the best method (asymptotic, bootstrap etc.) for calculating confidence intervals of LD50? i could "get rid" of Finney's fiducial confidence intervals but