similar to: Power analysis for Cox regression with a time-varying covariate

Hello Everyone,   I'm learning how to perform various statistical analyses in R. I'm checking my understanding by replicating examples from my SAS books. Below is an attempt to replicate a Cox Proportional Hazards model with a time-varying covariate. I think I'm doing this correctly but am not completely sure. I would appreciate it if someone could double-check my results. In case

Help! I am unsure if I can analyze data from the following experiment. Fish were placed in a tank at (t=0) Measurements of Carbon Dioxide were taken each day for 120 days (t=0,...120) A few fish were then randomly pulled out of the tank at different days, killed and examined for the presence of a disease T= time of examination in days from start (i.e. 85th day), E = 0/1 for nonevent/event My

I am using a syntax like coxph(Surv(start, stop, event) ~ X, data) to estimate the effect of X, which may change at each measurement (every 6 months). Is there anyone who knows a way to test the proportional hazard assumption in that case? Thank you in advance Jean-François Boudreau Sherbrooke University [[alternative HTML version deleted]]

I have a dataset with event=death time (from medical examination until death/censoring) dose (given at examination time) Two groups are considered, a non-exposed group (dose=0), an exposed group (dose between 5 and 60). For some reason there is a theory of the dose increasing its effect over time (however it was only given (and measured) once = at the time of examination). I tested a model:

Dear friends, I have used R for some time now and have a tricky question about the coxph-function: To sum it up, I am not sure whether I can use coxph in conjunction with missing covariate data in a model with time-variant covariates. The point is: I know how "old" every piece that I oberserve is, but do not have fully historical information about the corresponding covariates. Maybe you

Hello, coxph does not use any information that are in the dataset between event times (or "death times") , since computation only occurs at event times. For instance, removing observations when there is no event at that time in the whole dataset does not change the results: > set.seed(1) > data <- as.data.frame(cbind(start=c(1:5,1:5,1:4),stop=c(2:6,2:6,2:5),status=c(rep(

Dear R-users, I would like to determine the probability of event at specific time using cox model fit. On the development sample data I am able to get the probability of a event at time point(t). I need probability score of a event at specific time, using scoring scoring dataset which will have only covariates and not the response variables. Here is the sample code: n = 1000 beta1 = 2; beta2 =

Hello All, I am trying to use the unfold function in RcmdrPlugin.survival library, which converts the survival data with time varying covariates to the counting process notation. The problem is somehow, the event indicator created is not correct. Below is the data, I am trying to convert: CASE TRT FAILTIME FAILCENS SEX AGE IGG0 IGG28 IGG42 IGG84 IGG364 26003 A 11.2033

Dear All, I am a researcher doing research in plant growth and I have a statistical problem that seems to not be able to handle. Recently, I conducted an experiment about plant growing in three different nutrient-level sediments. I harvested these every three week (three harvests in all). Some growth traits of these plants were recorded (e.g. total biomass, leaf biomass and stem biomass). In

Hi All, I'm learning the R codes for Cox PH modeling. Could I ask you what the function of "factor" in modeling? Thank you! When dealing with the categorical covariates (for example 3 groups), it will come out different results if we add the command "factor" in front of the categorical covariate or not: if we don't add "factor", there is only one

Hi all, I am trying to detect association between a covariate and a disease outcome using R. This covariate shows time-varying effect, I add a time-covariate interaction item to build Cox model as follows: COX <- coxph(as.formula("Surv(TIME,outcome)~eGFR_BASE+eGFR_BASE:TIME"),ori.data); coef exp(coef) e(coef) z p eGFR_BASE

Dear UseRs, Suppose I have data regarding smoking habits of a prospective cohort and wish to determine the risk ratio of colorectal cancer in the smokers compared to the non-smokers. What do I do at the end of the study with people who die of heart disease? Can I just censor them exactly the same as people who become uncontactable or who die in a plane crash? If not, why not? I'm thinking

Hello everyone, I am searching for a covariate selection procedure in a cox model formulated as a counting process. I use intervals, my formula looks like coxph(Surv(start,stop,status)~ x1+x2+...+cluster(id),robust=T) where id is a country code (I study occurence of civil wars from 1962 to 1997). I'd like something not based on p-values, since they have several flaws for this purpose. I turned

dears, I like two write a program with R to estimate the coefficients of covariate,I like two know the original program for this programing for partial maximum likelihood for cox models with two co variate. I did it with coxph command, thanks [[alternative HTML version deleted]]

I was wondering if someone familiar with survival analysis can help me with the following. I would like to fit a Weibull curve, that may be dependent on a covariate, my dataframe "labdata" that has the fields "cov", "time", and "censor". Do I do the following? wieb<-survreg(Surv(labdata$time, labadata$censor)~labdata$cov,

Han-Lin I don't think I have seen a reply so I will suggest that maybe you could try a different approach than what you are thinking about doing. I believe the current best practice is to use the weights as a covariate in a regression model - and bytheway - the weights are the inverse of the probabilities of selection - not the probabilities. Fundamentally, there is a difficulty in making

Dear all, I am interested to evaluate reclassification using net reclassification improvement and Integrated Discrimination Index IDI after survival analysis (Cox proportional hazards using stcox). I search a R package or a R code that specifically addresses the categorical NRI for time-to-event data in the presence of censored observation and, if possible, at different follow-up time points. I

Dear all, I am having quite a hard time in trying to figure out how to correctly spell out a model in R (a repeated-measures anova with a within-subject covariate, I guess). Even though I have read in the posting guide that statistical advice may or may not get an answer on this list, I decided to try it anyway, hoping not to incur in somebody's ire for misusing the tool. For the sake of

Hi, I am wondering if anyone can explain to me if cumulative incidence (CI) is just "1 minus kaplan-Meier survival"? Under what circumstance, you should use cumulative incidence vs KM survival? If the relationship is just CI = 1-survival, then what difference it makes to use one vs. the other? And in R how I can draw a cumulative incidence plot. I know I can make a Kaplan-Meier

Good morning, Sorry to trouble the list. I have a problem I hope to seek your advice on. Essentially, I am trying to 'validate' a multivariate Cox proportional hazards model built in a training set, by testing it on an external test set. I have performed a survfit using the Cox model to predict survival for the test set, and obtained individual predictions for survival time, with