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2005 Jul 13
1
Fieller's Conf Limits and EC50's
...C 19 May 05
call <- match.call()
coef = coef(obj)
vcov = summary.glm(obj)$cov.unscaled
b0<-coef[1]
b1<-coef[2]
var.b0<-vcov[1,1]
var.b1<-vcov[2,2]
cov.b0.b1<-vcov[1,2]
alpha<-1-conf.level
zalpha.2 <- -qnorm(alpha/2)
gamma <- zalpha.2^2 * var.b1 / (b1^2)
eta = family(obj)$linkfun(p) #based on calcs in V&R's dose.p
EC50 <- (eta-b0)/b1
const1 <- (gamma/(1-gamma))*(EC50 + cov.b0.b1/var.b1)
const2a <- var.b0 + 2*cov.b0.b1*E...