Displaying 1 result from an estimated 1 matches for "vittinghoff".
2009 Jan 07
0
Frailty by strata interactions in coxph (or coxme)?
...l tothe data from a two arm (treatment indicator is 0/1)
multicenter trial, adjusting for the presence of covariates and testing for the presence of a center
(and possibly a treatment X center interaction effect).
I would like to contrast the different approaches discussed in Glidden D.V. and Eric Vittinghoff. Modelling clustered survival data from multicentre clinical trials. Stat Med 2004, 23:369-388 (DOI: 10.1002/sim. 1599). in this paper the authors present a decomposition of the hazard function for the ith individual, receiving Z(k,i) treatment (0-1) in the kth center as:
lambda(k,i)=lambda(0,k)*e...