search for: verum

Hallo! I have two groups (placebo/verum), every subject is measured at 5 times, the first time t0 is the baseline measurement, t1 to t4 are the measurements after applying the medication (placebo or verum). The question is, if there is a significant difference in the two groups and how large the differnce is (95% confidence intervals)....

...past I had asked this before, and never got a reply (in other cases, the response was within hours). I also checked the S-list, where several similar enquiries of other people are orphaned. We have a cross-over design, where patient are treated two weeks with placebo, two weeks with a drug ("verum"), and a washout phase in between. For each phase, there is ONE number (let's call it "glucose level") describing the treatment effect. Blind treatement sequence is Seq=1 for placebo/verum, Seq=2 for verum/placebo. In Pinheiro/Bates, cross-over trials are mentioned on page 107,...

Hello, I have a time-series that has some missing samples. I was thinking on completing them using either zero-order hold or linear interpolation. I am looking for an efiicient way (other than a loop...) of identifiying the missing time slots and filling them. Can you think of any methods that might help here? (obviously which(diff(time)>min(diff(time))) will give the locations, but what