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tika
2008 Nov 26
1
Request for Assistance in R with NonMem
...RUN# 3033 EFFECT COMP POPULATION PK-PD MODEL 2
$INPUT C REPL ID ARM TIME AGE BW GNDR DV MDV FLAG AMT EVID
;FLAG 1 = PK, FLAG 2=PD,
;CMT 1=GUT, 2=CENTRAL
;DV =PK ORDERED BY ID, TIME
$DATA ../projectRSD1.csv IGNORE=C
$SUBROUTINE ADVAN2 TRANS2 INFN=../MItoolsRunlogNM6.for
$ABB COMRES=8
$PK
FLA2=FLAG
TVKA=THETA(1)
TVCL=THETA(2)
TVV=THETA(3)
CL=TVCL*EXP(ETA(1))
V=TVV*EXP(ETA(2))
KA=TVKA*EXP(ETA(3))
S2=V
$ERROR
EMAX=THETA(4)*EXP(ETA(4))
EC50=THETA(5)*EXP(ETA(5))
N = THETA(6)*EXP(ETA(6))
EFF= (EMAX*F**N)/(EC50**N+F**N) + ERR(2)
CONC= F + F*ERR(1)
Y = CONC*(2-FLAG) + EFF*(FLAG-1)
IPRED=Y
" LAS...