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biexponential
2006 Apr 20
2
nlminb( ) : one compartment open PK model
All,
I have been able to successfully use the optim( ) function with
"L-BFGS-B" to find reasonable parameters for a one-compartment
open pharmacokinetic model. My loss function in this case was
squared error, and I made no assumptions about the distribution
of the plasma values. The model appeared to fit pretty well.
Out of curiosity, I decided to try to use nlminb( ) applied to
a