search for: toxicity

Hi i would like to use some graphs or tables to explore the data and make some sensible guesses of what to expect to see in a glm model to assess if toxin concentration and sex have a relationship with the kill rate of rats. But i cant seem to work it out as i have two predictor variables~help?Thanks.:) Here's my data. >

Hello everyone, I need to do a sample size calculation. The study two arms and two endpoints. The two arms are two different cancer drugs and the two endpoints reflect efficacy (based on progression free survival) and toxicity. Until now, I have been trying to understand this in terms of a one-arm design, where the acceptable rate of efficacy might be 0.40, the unacceptable rate of efficacy might be 0.20, the acceptable rate of non-toxicity might be 0.85, and the unacceptable rate of non-toxicity might be 0.65. Then on...

Dear all, I tried help.search("karber") and RSiteSearch("karber") and RSiteSearch("*karber*") to find whether the (trimmed) Spearman-Karber method for LD50 evaluation in toxicity data (e.g. according to Hamilton 1977) has been implemented in R. Or does this method feature under a different name? Of course logit and probit are doable, but Spearman-Karber seems to me to be the way I should go with our data. Thanks for all your help, Susanne Institute of Groundwater E...

...ed after outcomes from each cohort of patients becomes available, using exact computation or MCMC methods (via either BRugs or R2WinBUGS). ? Full functionality allowing a range prior distributions for the model parameter(s) as well as calculation of standardised doses from prior estimates of toxicity at each dose level ? The ability to choose the summary estimate of the posterior distribution used to select the next dose (options are posterior mean or plug-in mean toxicity or a quantile of the maximum tolerated dose (MTD) distribution, as in an EWOC design). ? Specification of a modifi...

...ed after outcomes from each cohort of patients becomes available, using exact computation or MCMC methods (via either BRugs or R2WinBUGS). ? Full functionality allowing a range prior distributions for the model parameter(s) as well as calculation of standardised doses from prior estimates of toxicity at each dose level ? The ability to choose the summary estimate of the posterior distribution used to select the next dose (options are posterior mean or plug-in mean toxicity or a quantile of the maximum tolerated dose (MTD) distribution, as in an EWOC design). ? Specification of a modifi...

Hi R experts, I have a data recoding problem I cant get my head around - I am not that great at the subsetting syntax. I have a dataset of longitudinal toxicity data (for multistate modelling) for which I want to also want to do a simple Kaplan-Meier curve of the time to first toxic event. The data for 2 cases presently looks like this (one with an event, the other without), with id representing each person on study, and follow-up time and status: >...

Hi All: I am working with a dataset on Arsenic toxicity, and I am trying to calculate the 20th, 40th, 60th, 80th, and highest percentiles for a variable, dietary Moisture (variable name dMoist). The inbuilt function quantile(dMoist) would print 0, 25th, 50th, 75th, and 100th percentile. Does there exist a function that can calculate xth percentile...

...ished trials. What I want to do is do a forrest (forest) plot for subgroups within my single dataset as a test of heterogeniety. I have a dataset who received either full dose(FD) or reduced dose(RD) treatment, and a number of characteristics about those subjects: age, sex, renal function, weight, toxicity. And I have survival data (censored). they are in standard columnar data. Is there an *easy* way to transform them into something like this: SubGroup n.FD n.RD surv.FD surv.RD 1 Age >65 2 Age <= 65 3 Male ... 9 Grade 0-2 Tox 10 Gra...

Dear Rxperts, Running the following code: ======================================================= twlo=10; twhi=20; wt=154; vd=0.5; cl=0.046; tau=6; t=3; F=1; wtkg <- wt/2.2 # convert lbs to kg vd.pt <- wtkg * vd # compute weight-based vd (L) cl.pt <- wtkg * cl # compute CL (L/hr) k <- cl.pt/vd.pt # compute k (hr^-1) cave <-

Hi all- So sorry to bother you all with something pretty basic. I am trying to add the lines method output from svysmooth to a svyplot with style="grayhex". However, the line either appears in the wrong place or if I am running in R Studio it causes the system to crash. I know this is something to do with Lattice graphics, but for the life of me I can not figure out how. Dr. Lumley

hi! i have a small problem with the game, my energy is black and toxicity too. Can you help me?

...lt;- crr(rel.t, rel.s, treatment, treatment, function(uft) cbind(ifelse(uft<=1,1,0),ifelse(uft>1,1,0)), failcode=1, cencode=0, na.action=na.omit, gtol-06, maxiter) fit1 where: rel.t = time to event (in years) rel.s = status , =1 if disease relapse, =2 if death from non disease related cause (toxicity of previous chemotherapy), =0 if alive & not in relapse treatment = binary covariate (value: 0 or 1) representing the treatment to test (different from chemotherapy above, with no known toxicity) I have not yet added other covariates in the model. this script gave me the following result: &gt...

Hi - I am trying to find and describe missing data in a time series. For instance, in the library openair, there is a data frame called "mydata": library(openair) head(mydata) date ws wd nox no2 o3 pm10 so2 co pm25 1 1998-01-01 00:00:00 0.60 280 285 39 1 29 4.7225 3.3725 NA 2 1998-01-01 01:00:00 2.16 230 NA NA NA 37 NA NA NA 3 1998-01-01 02:00:00

Hello all, Here's a PR I want to ask community about: should NUT clients like upsc report (log!) or hide the infamous 'Init SSL without certificate database' message? On one hand, it is a reminder that the setup is insecure (plaintext protocol, might be in an externally provided tunnel but we don't know that). On another, it is fairly annoying and if it does clutter

Hello all, Here's a PR I want to ask community about: should NUT clients like upsc report (log!) or hide the infamous 'Init SSL without certificate database' message? On one hand, it is a reminder that the setup is insecure (plaintext protocol, might be in an externally provided tunnel but we don't know that). On another, it is fairly annoying and if it does clutter

Version 1.1-8 of package 'scuba' has been uploaded to CRAN. 'scuba' is a package for scuba diving calculations and decompression models. It supports dive profiles (tables, plotting etc), analysis of dive profiles using decompression models, gas toxicity calculations, and gas usage calculations. New features in version 1.1-8: . support for dive profiles uploaded from a dive computer . new dataset: dive profile from a wreck dive on nitrox . bug fix in oxygen toxicity calculations Adrian Baddeley ____________________________________...

...ew developments from version 0.1: * Stopping rules have been added, allowing stopping to be based on a maximum sample size, the maximum number to be treated at the final MTD estimate, the precision of the MTD estimate, and a minumum sample size. * Implementation of escalation based on posterior toxicity intervals using loss functions. * Posterior summaries after each recruited cohort can now be plotted using the "each" argument of plot.bcrm. * When simulating, operating characteristics are also now presented by true regions of toxicity risk. * Simulations now run faster, as they use i...

...ew developments from version 0.1: * Stopping rules have been added, allowing stopping to be based on a maximum sample size, the maximum number to be treated at the final MTD estimate, the precision of the MTD estimate, and a minumum sample size. * Implementation of escalation based on posterior toxicity intervals using loss functions. * Posterior summaries after each recruited cohort can now be plotted using the "each" argument of plot.bcrm. * When simulating, operating characteristics are also now presented by true regions of toxicity risk. * Simulations now run faster, as they use i...

Happy Friday fellow R users. I need some help - I am trying to make a graph using ggplot 2 of some lead isotope ratios. Normally, the isotope mass number appears as a superscript before the chemical symbol. However, I cannot figure out how to do this ggplot2's axis labels. The closest I have come is using "." In front of the numbers I am superscripting e.g: ggplot(....

Hello - So I am trying to use ggplot2 to show a linear regression between two variables, but I want to also show the fit of the line on the graph as well. I am using ggplot2 for other graphics in what I am working on, so even though this would be a fairly easy thing to do in Excel, I would prefer to do it in R to keep my look and feel, and I think ggplot2 is just cooler. Here is a sample