search for: toxicity

Displaying 20 results from an estimated 84 matches for "toxicity".

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2010 Oct 04
2
Plot for Binomial GLM
Hi i would like to use some graphs or tables to explore the data and make some sensible guesses of what to expect to see in a glm model to assess if toxin concentration and sex have a relationship with the kill rate of rats. But i cant seem to work it out as i have two predictor variables~help?Thanks.:) Here's my data. >
2011 Aug 04
1
Multiple endpoint (possibly group sequential) sample size calculation
Hello everyone, I need to do a sample size calculation. The study two arms and two endpoints. The two arms are two different cancer drugs and the two endpoints reflect efficacy (based on progression free survival) and toxicity. Until now, I have been trying to understand this in terms of a one-arm design, where the acceptable rate of efficacy might be 0.40, the unacceptable rate of efficacy might be 0.20, the acceptable rate of non-toxicity might be 0.85, and the unacceptable rate of non-toxicity might be 0.65. Then on...
2009 Feb 20
0
Spearman-Karber method for toxicity data
Dear all, I tried help.search("karber") and RSiteSearch("karber") and RSiteSearch("*karber*") to find whether the (trimmed) Spearman-Karber method for LD50 evaluation in toxicity data (e.g. according to Hamilton 1977) has been implemented in R. Or does this method feature under a different name? Of course logit and probit are doable, but Spearman-Karber seems to me to be the way I should go with our data. Thanks for all your help, Susanne Institute of Groundwater E...
2012 Jan 13
0
New package ‘bcrm’ to implement Bayesian continuous reassessment method designs
...ed after outcomes from each cohort of patients becomes available, using exact computation or MCMC methods (via either BRugs or R2WinBUGS). ? Full functionality allowing a range prior distributions for the model parameter(s) as well as calculation of standardised doses from prior estimates of toxicity at each dose level ? The ability to choose the summary estimate of the posterior distribution used to select the next dose (options are posterior mean or plug-in mean toxicity or a quantile of the maximum tolerated dose (MTD) distribution, as in an EWOC design). ? Specification of a modifi...
2012 Jan 13
0
New package ‘bcrm’ to implement Bayesian continuous reassessment method designs
...ed after outcomes from each cohort of patients becomes available, using exact computation or MCMC methods (via either BRugs or R2WinBUGS). ? Full functionality allowing a range prior distributions for the model parameter(s) as well as calculation of standardised doses from prior estimates of toxicity at each dose level ? The ability to choose the summary estimate of the posterior distribution used to select the next dose (options are posterior mean or plug-in mean toxicity or a quantile of the maximum tolerated dose (MTD) distribution, as in an EWOC design). ? Specification of a modifi...
2007 Apr 23
1
data recoding problem
Hi R experts, I have a data recoding problem I cant get my head around - I am not that great at the subsetting syntax. I have a dataset of longitudinal toxicity data (for multistate modelling) for which I want to also want to do a simple Kaplan-Meier curve of the time to first toxic event. The data for 2 cases presently looks like this (one with an event, the other without), with id representing each person on study, and follow-up time and status: >...
2004 Apr 26
2
Looking for help in calculating percentiles
Hi All: I am working with a dataset on Arsenic toxicity, and I am trying to calculate the 20th, 40th, 60th, 80th, and highest percentiles for a variable, dietary Moisture (variable name dMoist). The inbuilt function quantile(dMoist) would print 0, 25th, 50th, 75th, and 100th percentile. Does there exist a function that can calculate xth percentile...
2009 Jul 28
5
Summarising Data for Forrest Plots
...ished trials. What I want to do is do a forrest (forest) plot for subgroups within my single dataset as a test of heterogeniety. I have a dataset who received either full dose(FD) or reduced dose(RD) treatment, and a number of characteristics about those subjects: age, sex, renal function, weight, toxicity. And I have survival data (censored). they are in standard columnar data. Is there an *easy* way to transform them into something like this: SubGroup n.FD n.RD surv.FD surv.RD 1 Age >65 2 Age <= 65 3 Male ... 9 Grade 0-2 Tox 10 Gra...
2010 May 02
2
Calculation error
Dear Rxperts, Running the following code: ======================================================= twlo=10; twhi=20; wt=154; vd=0.5; cl=0.046; tau=6; t=3; F=1; wtkg <- wt/2.2 # convert lbs to kg vd.pt <- wtkg * vd # compute weight-based vd (L) cl.pt <- wtkg * cl # compute CL (L/hr) k <- cl.pt/vd.pt # compute k (hr^-1) cave <-
2012 Oct 18
3
svyplot and svysmooth with hexbin
Hi all- So sorry to bother you all with something pretty basic. I am trying to add the lines method output from svysmooth to a svyplot with style="grayhex". However, the line either appears in the wrong place or if I am running in R Studio it causes the system to crash. I know this is something to do with Lattice graphics, but for the life of me I can not figure out how. Dr. Lumley
2011 Jul 12
16
The Witcher
hi! i have a small problem with the game, my energy is black and toxicity too. Can you help me?
2008 Aug 22
1
Help on competing risk package cmprsk with time dependent covariate
...lt;- crr(rel.t, rel.s, treatment, treatment, function(uft) cbind(ifelse(uft<=1,1,0),ifelse(uft>1,1,0)), failcode=1, cencode=0, na.action=na.omit, gtol-06, maxiter) fit1 where: rel.t = time to event (in years) rel.s = status , =1 if disease relapse, =2 if death from non disease related cause (toxicity of previous chemotherapy), =0 if alive & not in relapse treatment = binary covariate (value: 0 or 1) representing the treatment to test (different from chemotherapy above, with no known toxicity) I have not yet added other covariates in the model. this script gave me the following result: &gt...
2012 Feb 13
2
finding and describing missing data runs in a time series
Hi - I am trying to find and describe missing data in a time series. For instance, in the library openair, there is a data frame called "mydata": library(openair) head(mydata) date ws wd nox no2 o3 pm10 so2 co pm25 1 1998-01-01 00:00:00 0.60 280 285 39 1 29 4.7225 3.3725 NA 2 1998-01-01 01:00:00 2.16 230 NA NA NA 37 NA NA NA 3 1998-01-01 02:00:00
2022 Sep 16
4
Fwd: [networkupstools/nut] Hide 'Init SSL without certificate database' message for upsc (PR #1662)
Hello all, Here's a PR I want to ask community about: should NUT clients like upsc report (log!) or hide the infamous 'Init SSL without certificate database' message? On one hand, it is a reminder that the setup is insecure (plaintext protocol, might be in an externally provided tunnel but we don't know that). On another, it is fairly annoying and if it does clutter
2022 Sep 16
4
Fwd: [networkupstools/nut] Hide 'Init SSL without certificate database' message for upsc (PR #1662)
Hello all, Here's a PR I want to ask community about: should NUT clients like upsc report (log!) or hide the infamous 'Init SSL without certificate database' message? On one hand, it is a reminder that the setup is insecure (plaintext protocol, might be in an externally provided tunnel but we don't know that). On another, it is fairly annoying and if it does clutter
2007 Sep 11
0
scuba 1.1-8
Version 1.1-8 of package 'scuba' has been uploaded to CRAN. 'scuba' is a package for scuba diving calculations and decompression models. It supports dive profiles (tables, plotting etc), analysis of dive profiles using decompression models, gas toxicity calculations, and gas usage calculations. New features in version 1.1-8: . support for dive profiles uploaded from a dive computer . new dataset: dive profile from a wreck dive on nitrox . bug fix in oxygen toxicity calculations Adrian Baddeley ____________________________________...
2012 May 02
0
bcrm package update
...ew developments from version 0.1: * Stopping rules have been added, allowing stopping to be based on a maximum sample size, the maximum number to be treated at the final MTD estimate, the precision of the MTD estimate, and a minumum sample size. * Implementation of escalation based on posterior toxicity intervals using loss functions. * Posterior summaries after each recruited cohort can now be plotted using the "each" argument of plot.bcrm. * When simulating, operating characteristics are also now presented by true regions of toxicity risk. * Simulations now run faster, as they use i...
2012 May 02
0
bcrm package update
...ew developments from version 0.1: * Stopping rules have been added, allowing stopping to be based on a maximum sample size, the maximum number to be treated at the final MTD estimate, the precision of the MTD estimate, and a minumum sample size. * Implementation of escalation based on posterior toxicity intervals using loss functions. * Posterior summaries after each recruited cohort can now be plotted using the "each" argument of plot.bcrm. * When simulating, operating characteristics are also now presented by true regions of toxicity risk. * Simulations now run faster, as they use i...
2011 Sep 30
2
isotope superscripts ggplot2
Happy Friday fellow R users. I need some help - I am trying to make a graph using ggplot 2 of some lead isotope ratios. Normally, the isotope mass number appears as a superscript before the chemical symbol. However, I cannot figure out how to do this ggplot2's axis labels. The closest I have come is using "." In front of the numbers I am superscripting e.g: ggplot(....
2011 Nov 10
2
ggplot2 - regression statistics how to display on plot
Hello - So I am trying to use ggplot2 to show a linear regression between two variables, but I want to also show the fit of the line on the graph as well. I am using ggplot2 for other graphics in what I am working on, so even though this would be a fairly easy thing to do in Excel, I would prefer to do it in R to keep my look and feel, and I think ggplot2 is just cooler. Here is a sample