search for: toxic

...tables to explore the data and make some sensible guesses of what to expect to see in a glm model to assess if toxin concentration and sex have a relationship with the kill rate of rats. But i cant seem to work it out as i have two predictor variables~help?Thanks.:) Here's my data. > rat.toxic<-read.table(file="Rats.csv",header=T,row.names=NULL,sep=",") > attach(rat.toxic) > names(rat.toxic) [1] "Dose" "Sex" "Dead" "Alive" > rat.toxic Dose Sex Dead Alive 1 10 F 1 19 2 10 M 0 20 3 20...

Hello everyone, I need to do a sample size calculation. The study two arms and two endpoints. The two arms are two different cancer drugs and the two endpoints reflect efficacy (based on progression free survival) and toxicity. Until now, I have been trying to understand this in terms of a one-arm design, where the acceptable rate of efficacy might be 0.40, the unacceptable rate of efficacy might be 0.20, the acceptable rate of non-toxicity might be 0.85, and the unacceptable rate of non-toxicity might be 0.65. Then...

Dear all, I tried help.search("karber") and RSiteSearch("karber") and RSiteSearch("*karber*") to find whether the (trimmed) Spearman-Karber method for LD50 evaluation in toxicity data (e.g. according to Hamilton 1977) has been implemented in R. Or does this method feature under a different name? Of course logit and probit are doable, but Spearman-Karber seems to me to be the way I should go with our data. Thanks for all your help, Susanne Institute of Groundwate...

...ed after outcomes from each cohort of patients becomes available, using exact computation or MCMC methods (via either BRugs or R2WinBUGS). ? Full functionality allowing a range prior distributions for the model parameter(s) as well as calculation of standardised doses from prior estimates of toxicity at each dose level ? The ability to choose the summary estimate of the posterior distribution used to select the next dose (options are posterior mean or plug-in mean toxicity or a quantile of the maximum tolerated dose (MTD) distribution, as in an EWOC design). ? Specification of a mod...

...ed after outcomes from each cohort of patients becomes available, using exact computation or MCMC methods (via either BRugs or R2WinBUGS). ? Full functionality allowing a range prior distributions for the model parameter(s) as well as calculation of standardised doses from prior estimates of toxicity at each dose level ? The ability to choose the summary estimate of the posterior distribution used to select the next dose (options are posterior mean or plug-in mean toxicity or a quantile of the maximum tolerated dose (MTD) distribution, as in an EWOC design). ? Specification of a mod...

Hi R experts, I have a data recoding problem I cant get my head around - I am not that great at the subsetting syntax. I have a dataset of longitudinal toxicity data (for multistate modelling) for which I want to also want to do a simple Kaplan-Meier curve of the time to first toxic event. The data for 2 cases presently looks like this (one with an event, the other without), with id representing each person on study, and follow-up time and status: &g...

Hi All: I am working with a dataset on Arsenic toxicity, and I am trying to calculate the 20th, 40th, 60th, 80th, and highest percentiles for a variable, dietary Moisture (variable name dMoist). The inbuilt function quantile(dMoist) would print 0, 25th, 50th, 75th, and 100th percentile. Does there exist a function that can calculate xth percent...

...ished trials. What I want to do is do a forrest (forest) plot for subgroups within my single dataset as a test of heterogeniety. I have a dataset who received either full dose(FD) or reduced dose(RD) treatment, and a number of characteristics about those subjects: age, sex, renal function, weight, toxicity. And I have survival data (censored). they are in standard columnar data. Is there an *easy* way to transform them into something like this: SubGroup n.FD n.RD surv.FD surv.RD 1 Age >65 2 Age <= 65 3 Male ... 9 Grade 0-2 Tox 10...

...DL wDm (mg) 18.8 10.8 8.0 14.3 658.0 658.0 But, there is an error from R? AR * total_dose_tau = 658 but that is wrong Total Dose (mg) = 279 * AR (=2.4) = 670 Please help. I don't want to harm anyone. A difference of 12 mg of a highly toxic drug can at the very least cause significant harm. -- Oscar Oscar A. Linares, MD Translational Medicine Unit La Plaisance Bay, Bolles Harbor Monroe, Michigan 48161 Department of Medicine, University of Toledo College of Medicine Toledo, OH 43606-3390 Department of Internal Medicine, The Detroi...

...) s1 <-svysmooth(api00~api99, dclus2) lines(s1) #works svyplot(api00~api99, dclus2, style="grayhex") lines(s1) #does not work (line either appears in the wrong position in RGui or crashes RStudio). VR James James T. Durant, MSPH CIH Environmental Health Scientist US Agency for Toxic Substances and Disease Registry Atlanta, GA 30341 770-488-0668 [[alternative HTML version deleted]]

hi! i have a small problem with the game, my energy is black and toxicity too. Can you help me?

...lt;- crr(rel.t, rel.s, treatment, treatment, function(uft) cbind(ifelse(uft<=1,1,0),ifelse(uft>1,1,0)), failcode=1, cencode=0, na.action=na.omit, gtol-06, maxiter) fit1 where: rel.t = time to event (in years) rel.s = status , =1 if disease relapse, =2 if death from non disease related cause (toxicity of previous chemotherapy), =0 if alive & not in relapse treatment = binary covariate (value: 0 or 1) representing the treatment to test (different from chemotherapy above, with no known toxicity) I have not yet added other covariates in the model. this script gave me the following result:...

...can use that I know about is timePlot in the openair package with statistic="frequency" but it only gives monthly summary data, and does not tell me if the missing data are clumped together or are dispersed. VR Jim James T. Durant, MSPH CIH Emergency Response Coordinator US Agency for Toxic Substances and Disease Registry Atlanta, GA 30341 770-378-1695 [[alternative HTML version deleted]]

...t certificate database' message? On one hand, it is a reminder that the setup is insecure (plaintext protocol, might be in an externally provided tunnel but we don't know that). On another, it is fairly annoying and if it does clutter syslog/journal from cron jobs etc. - is also somewhat toxic (causes I/O, uses space) if deployment owner is not going to do anything about it anyway for whatever reason (LAN, VPN, SSH tunnel...). That PR proposes to hide the message by default, with debug level 1. One alternative is to use debug level 0 so it always pops up on stderr like now, but does n...

...t certificate database' message? On one hand, it is a reminder that the setup is insecure (plaintext protocol, might be in an externally provided tunnel but we don't know that). On another, it is fairly annoying and if it does clutter syslog/journal from cron jobs etc. - is also somewhat toxic (causes I/O, uses space) if deployment owner is not going to do anything about it anyway for whatever reason (LAN, VPN, SSH tunnel...). That PR proposes to hide the message by default, with debug level 1. One alternative is to use debug level 0 so it always pops up on stderr like now, but does n...

Version 1.1-8 of package 'scuba' has been uploaded to CRAN. 'scuba' is a package for scuba diving calculations and decompression models. It supports dive profiles (tables, plotting etc), analysis of dive profiles using decompression models, gas toxicity calculations, and gas usage calculations. New features in version 1.1-8: . support for dive profiles uploaded from a dive computer . new dataset: dive profile from a wreck dive on nitrox . bug fix in oxygen toxicity calculations Adrian Baddeley _________________________________...

...ew developments from version 0.1: * Stopping rules have been added, allowing stopping to be based on a maximum sample size, the maximum number to be treated at the final MTD estimate, the precision of the MTD estimate, and a minumum sample size. * Implementation of escalation based on posterior toxicity intervals using loss functions. * Posterior summaries after each recruited cohort can now be plotted using the "each" argument of plot.bcrm. * When simulating, operating characteristics are also now presented by true regions of toxicity risk. * Simulations now run faster, as they us...

...ew developments from version 0.1: * Stopping rules have been added, allowing stopping to be based on a maximum sample size, the maximum number to be treated at the final MTD estimate, the precision of the MTD estimate, and a minumum sample size. * Implementation of escalation based on posterior toxicity intervals using loss functions. * Posterior summaries after each recruited cohort can now be plotted using the "each" argument of plot.bcrm. * When simulating, operating characteristics are also now presented by true regions of toxicity risk. * Simulations now run faster, as they us...

...e.g: ggplot(.... +xlab(expression(.^207*"Pb/"*.^206*"Pb"))+ylab(expression(.^208*"Pb/"*.^206*"Pb") I have searched for this and have not had any luck so far... any suggestions? VR Jim James T. Durant, MSPH, CIH Emergency Response Coordinator DIvision of Toxicology and Environmental Medicine US Agency for Toxic Substances and Disease Registy Mailing Address: 4770 Buford Highway, MS F-62 Atlanta, Georgia 30341 Telephone: 770-488-0668 (office) 770-378-1695 (cell) [[alternative HTML version deleted]]

...accomplish: df<-NULL df$x<-rnorm(100) df$y<-rnorm(100) df<-data.frame(df) ggplot(df, aes(x=x,y=y))+geom_point()+geom_smooth(method=lm) # would like to be able to showr squared and slope/intercept of lm VR Jim James T. Durant, MSPH CIH Emergency Response Coordinator US Agency for Toxic Substances and Disease Registry Atlanta, GA 30341 770-378-1695 [[alternative HTML version deleted]]