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Hi, I am attempting to use phyper to test the significance of two overlapping lists. I keep getting a zero and wondered if that was determining non-significance of my overlap or a p-value too small to calculate? overlap = 524 lista = 2784 totalpop = 54675 listb = 1296 phyper(overlap, lista, totalpop, listb,lower.tail = FALSE, log.p=F) [1] 0 If I plug in some different values I get a p-value but since zero is actually lower is the overlap significant, or more likely have I made a mistake in using the function? phyper(10, 100, 20000, 100,low...