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...issue is the answer to the questions: "What should I do next?" or "What am I allowed to do here?" A "nice" interface, not necessarily GUI, will offer friendly answers: "I was expecting you to do _this_" or "In this situation you are allowed to do _these things_" You see, it's all a matter of _expectations_, which you statisticians are very good at computing. An application interface is a language, a dialog really, which has its own grammar and productions. A good interface should be able to recognize (in this dialog-language) the kinds of things...