search for: tamoxifen

Hi, I was reading a paper published in JCO "Prediction of risk of distant recurrence using 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study" (ICO 2010 28: 1829). The author uses a method to estimate the 9-year risk of distant recurrence as a function of continuous recurrence score (RS). The method is special as author states: ? "To define the continuous relation between RS, as a linear covariate, and 9-year...

...input and computes a curve giving log hazard ratio (or rate of failure for a specific time) as a function of the continuous covariate, as well as curves giving +-SE for that curve. A plot of this nature can also be found as figure 4 in Paik, et al., "A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer," 2004, New England Journal of Medicine, pp 2817-26. Any help would be greatly appreciated. Thanks. -Ben Ben Wittner Research fellow, MGH & Harvard Medical School wittner.ben at mgh.harvard.edu