search for: symmetrictwo

...ion about Pocock and OBF boundary. As far as Iunderstand, these 2 boundaries require equal spacing between interim analyses(maybe this is not correct?). But I can still use gsDesign to run an analysisbased on unequal spacing:?gsDesign(k=2,test.type=2,timing=c(0.75,1),alpha=0.05,sfu='Pocock')Symmetrictwo-sided group sequential design with90 %power and 5 % Type I Error.Spendingcomputations assume trial stops if a bound is crossed.???????????Sample???????????Size ??AnalysisRatio*? Z?? Nominal p? Spend????????1? 0.796 1.82??? 0.0346 0.0346????????2? 1.061 1.82??? 0.0346 0.0154????Total????????????????...

...ion about Pocock and OBF boundary. As far as Iunderstand, these 2 boundaries require equal spacing between interim analyses(maybe this is not correct?). But I can still use gsDesign to run an analysisbased on unequal spacing: gsDesign(k=2,test.type=2,timing=c(0.75,1),alpha=0.05,sfu='Pocock')Symmetrictwo-sided group sequential design with90 %power and 5 % Type I Error.Spendingcomputations assume trial stops if a bound is crossed. Sample Size AnalysisRatio* Z Nominal p Spend 1 0.796 1.82 0.0346 0.0346 2 1.061 1.82 0.0346 0.0154 Total...

...ion about Pocock and OBF boundary. As far as Iunderstand, these 2 boundaries require equal spacing between interim analyses(maybe this is not correct?). But I can still use gsDesign to run an analysisbased on unequal spacing: gsDesign(k=2,test.type=2,timing=c(0.75,1),alpha=0.05,sfu='Pocock')Symmetrictwo-sided group sequential design with90 %power and 5 % Type I Error.Spendingcomputations assume trial stops if a bound is crossed.? ? ? ? ? Sample? ? ? ? ? Size? AnalysisRatio*? Z? Nominal p? Spend? ? ? ? 1? 0.796 1.82? ? 0.0346 0.0346? ? ? ? 2? 1.061 1.82? ? 0.0346 0.0154? ? Total? ? ? ? ? ? ? ? ? ?...

...and OBF boundary. As far as Iunderstand, these 2 boundaries >require equal spacing between interim analyses(maybe this is not >correct?). But I can still use gsDesign to run an analysisbased on >unequal spacing: >gsDesign(k=2,test.type=2,timing=c(0.75,1),alpha=0.05,sfu='Pocock')Symmetrictwo-sided >group sequential design with90 %power and 5 % Type I >Error.Spendingcomputations assume trial stops if a bound is crossed.? ? >? ? ? Sample? ? ? ? ? Size? AnalysisRatio*? Z? Nominal p? Spend? ? ? ? >1? 0.796 1.82? ? 0.0346 0.0346? ? ? ? 2? 1.061 1.82? ? 0.0346 0.0154? ? >Total...