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2004 Dec 20
1
Re: [BioC] limma, FDR, and p.adjust
Mark, there is a fdr website link via Yoav Benjamini's homepage which is: http://www.math.tau.ac.il/%7Eroee/index.htm On it you can download an S-Plus function (under the downloads link) which calculates the false discovery rate threshold alpha level using stepup, stepdown, dependence methods etc. Some changes are required to the plotting code when porting it to R. I removed the xaxs="s" arguement on line 80. The fdr function requires a list of p-values as input, a Q-value (*expected* false discovery rate control at level Q) and a required method...
2004 Dec 20
1
[BioC] limma, FDR, and p.adjust
You asked the same question on the Bioconductor mailing list back in August. At that time, you suggested yourself a solution for how the adjusted p-values should be interpreted. I answered your query and told you that your interpretation was correct. So I'm not sure what more can be said, except that you should read the article Wright (1992), which is cited in the help entry for p.adjust(),