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...e rule of thumb for a Cox model of 20 events per variable (not n=20). Many microarray studies will have very marginal sample size. 2. If you are looking at many genes then a completely different strategy is required. There is a large and growing literature; I like Newton et al, Annals of Applied Statistictis, 2007, 85-106 as an intro; but expect to read much more. Terry Therneau -------- begin included message --------- I want to test the expression of a subset of genes for correlation with patient survival. I found out that the coxph function is appropriate for doing this since it works with c...