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Hi, I'm trying to use Robust non-linear regression to fit dose response curves. Maybe I didnt look good enough, but I dind't find robust methods for NON linear regression implemented in R. A method that looked good to me but is unfortunately not (yet) implemented in R is described in http://www.graphpad.com/articles/RobustNonlinearRegression_files/frame.htm

Your understanding isn't similar to mine. Mine says robust/resistant methods are for data with heavy tails, not heteroscedasticity. The common ways to approach heteroscedasticity are transformation and weighting. The first is easy and usually quite effective for dose-response data. The second is not much harder. Both can be done in R with nls(). Andy From: Quin Wills > > I am

I am using "nls" to fit dose-response curves but am not sure how to approach more robust regression in R to get around the problem of the my error showing increased variance with increasing dose. My understanding is that "rlm" or "lqs" would not be a good idea here. 'Fairly new to regression work, so apologies if I'm missing something obvious.