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Hi all! I am working on a nested lme model with one fixed effect ("treatment", which 3 levels) and two random effects for "Individuals" (four of them) within "treatment" and "replicate -2 levels-" within "individual" within "treatment". For doing so, I´ve been trying to create a factor for Individual%in%Treatment, say IT by

Hi, R users, I'm using the "lme" function in R to estimate a 2 level mixed effects model, in which the size of the subject groups are different. It turned out that It takes forever for R to converge. I also tried the same thing in SPSS and SPSS can give the results out within 20 minutes. Anyone can give me some advice on the lme function in R, especially why R does not converge?