search for: pocockboundary

...with90 %power and 5 % Type I Error.Spendingcomputations assume trial stops if a bound is crossed.???????????Sample???????????Size ??AnalysisRatio*? Z?? Nominal p? Spend????????1? 0.796 1.82??? 0.0346 0.0346????????2? 1.061 1.82??? 0.0346 0.0154????Total??????????????????????0.0500 ?++alpha spending:Pocockboundary.*Sample size ratio compared to fixed design with no interim?Can anyone share some light whether the above analysis is stillvalid? Or for unequal spacing, I have to use Lan-Demet?s error spendingfunction approximations??Thank you, [[alternative HTML version deleted]]

...with90 %power and 5 % Type I Error.Spendingcomputations assume trial stops if a bound is crossed. Sample Size AnalysisRatio* Z Nominal p Spend 1 0.796 1.82 0.0346 0.0346 2 1.061 1.82 0.0346 0.0154 Total 0.0500 ++alpha spending:Pocockboundary.*Sample size ratio compared to fixed design with no interim Can anyone share some light whether the above analysis is stillvalid? Or for unequal spacing, I have to use Lan-Demet?s error spendingfunction approximations? Thank you, > [[alternative HTML version deleted]] > Your example code i...

...ign with90 %power and 5 % Type I Error.Spendingcomputations assume trial stops if a bound is crossed.? ? ? ? ? Sample? ? ? ? ? Size? AnalysisRatio*? Z? Nominal p? Spend? ? ? ? 1? 0.796 1.82? ? 0.0346 0.0346? ? ? ? 2? 1.061 1.82? ? 0.0346 0.0154? ? Total? ? ? ? ? ? ? ? ? ? ? 0.0500? ++alpha spending:Pocockboundary.*Sample size ratio compared to fixed design with no interim Can anyone share some light whether the above analysis is stillvalid? Or for unequal spacing, I have to use Lan-Demet?s error spendingfunction approximations? Thank you, > ??? [[alternative HTML version deleted]] > Your example cod...

...d 5 % Type I >Error.Spendingcomputations assume trial stops if a bound is crossed.? ? >? ? ? Sample? ? ? ? ? Size? AnalysisRatio*? Z? Nominal p? Spend? ? ? ? >1? 0.796 1.82? ? 0.0346 0.0346? ? ? ? 2? 1.061 1.82? ? 0.0346 0.0154? ? >Total? ? ? ? ? ? ? ? ? ? ? 0.0500? ++alpha >spending:Pocockboundary.*Sample size ratio compared to fixed design >with no interim Can anyone share some light whether the above analysis >is stillvalid? Or for unequal spacing, I have to use Lan-Demet?s error >spendingfunction approximations? Thank you, >> ??? [[alternative HTML version deleted]] >&gt...