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I need to calculate a large number of t statistics, and would like to do so via matrix operations. So far I have figured out a way to calculate the mean of each row of the matrix: d <- matrix(runif(100000,1,10), 1000, 10) # some test data s <- rep(1,ncol(d)) # a sum vector to use for matrix multiplication means <- (d%*%s)/ncol(d) This is at least 1 order of magnitude faster than