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medsci
2003 Jul 10
1
group sequential and adaptive designs
Hello R users,
I am looking for R (or S) code related to group sequential or adaptive
designs for clinical trials. (The most prominent examples are the designs of
Pocock or O'Brien/Fleming, the alpha-spending function approach, or Fisher's
combination test and the inverse normal method.) I am particularly interested in
the calculation of the critical boundaries, the handling of spending