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Hello all, I believe this can be done using bootstrap, but I am wondering if there is some other way that might be used to tackle this. #Let's say I have two pairs of samples: set.seed(100) s1 <- rnorm(100) s2 <- s1 + rnorm(100) x1 <- s1[1:99] y1 <- s2[1:99] x2 <- x1 y2 <- s2[2:100] #And both yield the following two correlations: cor(x1,y1) # 0.7568969 (cor1) cor(x2,y2)