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2010 Dec 13
2
Complicated nls formula giving singular gradient message
...a regression in R that I normally use Prism for, because the formula isn't pretty by any means. Prism presents the formula (which is in the Prism equation library as Heterologous competition with depletion, if anyone is curious) in these segments: KdCPM = KdnM*SpAct*Vol*1000 R=NS+1 S=(1+10^(X-LogKi))*KdCPM+Hot a=-1*R b=R*S+NS*Hot+BMax c = -1*Hot*(S*MS+BMax) Y = (-1*b+sqrt(b*b-4*a*c))/(2*a) I'm only trying to solve for NS, LogKi, and BMax. I have everything else (KdnM, SpAct, Vol, Hot). I would use the simple formula at the bottom and then backsolve for the terms I'm looking for, but...