search for: landemets

...6524, 0.6527, 0.653, 0.6534, 0.6537, 0.6541, 0.6544, 0.6547, 0.6551, 0.6554) hc <- c(rep(1.05e-02, 2), rep(2.09e-02, 3), rep(4.19e-02, 15)) hd1B <- c(0.1109, 0.1381, 0.1485, 0.1637, 0.2446, 0.2497, 0) test.example <- PwrGSD( EfficacyBoundary=LanDemets(alpha=0.05, spending= ObrienFleming), FutilityBoundary=LanDemets(alpha=0.1,spending=ObrienFleming), RR.Futility = 0.82, sided="<",method="A",accru =7.73, accrat=9818.65, tlook =tlook, tcut0 =t0, h0=h0, tcut1=t0, rhaz=rhaz, tcutc0=t0, hc0=h...

...6524, 0.6527, 0.653, 0.6534, 0.6537, 0.6541, 0.6544, 0.6547, 0.6551, 0.6554) hc <- c(rep(1.05e-02, 2), rep(2.09e-02, 3), rep(4.19e-02, 15)) hd1B <- c(0.1109, 0.1381, 0.1485, 0.1637, 0.2446, 0.2497, 0) test.example <- PwrGSD( EfficacyBoundary=LanDemets(alpha=0.05, spending= ObrienFleming), FutilityBoundary=LanDemets(alpha=0.1,spending=ObrienFleming), RR.Futility = 0.82, sided="<",method="A",accru =7.73, accrat=9818.65, tlook =tlook, tcut0 =t0, h0=h0, tcut1=t0, rhaz=rhaz, tcutc0=t0, hc0=h...

Hello R users, I am looking for R (or S) code related to group sequential or adaptive designs for clinical trials. (The most prominent examples are the designs of Pocock or O'Brien/Fleming, the alpha-spending function approach, or Fisher's combination test and the inverse normal method.) I am particularly interested in the calculation of the critical boundaries, the handling of spending