search for: heterozygote

...hods for creating, representing, and manipulating genotypes (unordered allele pairs) and haplotypes (ordered allele pairs). Genotypes and haplotypes can be annotated with chromosome, locus, gene, and marker information. Utility functions compute genotype and allele frequencies, flag homozygotes or heterozygotes, flag allele carriers of certain alleles, count the number of a specific allele carried by an individual, extract one or both alleles, estimate and generate confidence intervals for measures of single-marker disequlibrium, and test for departure from Hardy-Weinberg equilibrium. The package descri...

...hods for creating, representing, and manipulating genotypes (unordered allele pairs) and haplotypes (ordered allele pairs). Genotypes and haplotypes can be annotated with chromosome, locus, gene, and marker information. Utility functions compute genotype and allele frequencies, flag homozygotes or heterozygotes, flag allele carriers of certain alleles, count the number of a specific allele carried by an individual, extract one or both alleles, estimate and generate confidence intervals for measures of single-marker disequlibrium, and test for departure from Hardy-Weinberg equilibrium. The package descri...

...d by the many R packages available to do such analysis. Here is my case: I've got a list of genes, and a number of case-control population pairs, and for each population and gene, the various genotypes that have been found. I've got both aggregate data (ex. gene1: homozygote wildtype: 201, heterozygote mutation carrier: 34, homozygote mutation carrier: 5) and per-gene data (i.e. for gene1 a list of e.g. "V/V", "V/I", "II" etc). The question asked is whether there is a difference in the mutation pattern between the case and the control groups influencing the outcome,...