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frattola
2010 May 18
1
proportion of treatment effect by a surrogate (fitting multivariate survival model)
Dear R-help,
I would like to compute the variance for the proportion of treatment
effect by a surrogate in a survival model (Lin, Fleming, and De
Gruttola 1997 in Statistics in Medicine). The paper mentioned that
the covariance matrix matches that of the covariance matrix estimator
for the marginal hazard modelling of multiple events data (Wei, Lin,
and Weissfeld 1989 JASA), and is implemented in Lin's MULCOX2, SAS,
and S-plus.
Is this the way...