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quantile
2004 Jul 29
0
Re: [BioC] normalisation for universal reference in 2 channel arrays
...>>what is down-regulated looks down-regulated. The difference is that the
>>down-regulated (and not in the up), so so much more down-regulated in one
>>of the batches. It looks like to be that the universal has more mRNA
>>abundance in one batch over the other.
>
>Gquantile won't help because it doesn't change the M-values. (It is
>intended for use with single channel analyses.) You could try 'quantile'
>or 'scale' normalization (not both) but there are no magic bullets in a
>situation like this. If you use 'scale normalization,...