search for: frds

Dear List, We are planning a genotyping study to be analyzed using false discovery rates (FDRs) (See Storey and Tibshirani PNAS 2003; 100:9440-5). I am interested in learning if there is any consensus as to how many features (ie. how many P values) need to be studied before reasonably reliable FDRs can be derived. Does anyone know of a citation where this is discussed? Bill Dupont William D.

...Two thoughts on this: 1. Your FDR (Not Franklin Delano Roosevelt) sounds like another name for Type I error rate. The definition of "reasonably reliable FDRs" would seem to relate to the status of the literature on this issue among researchers in genotyping. As more reports of FRDs in genotyping are published, I would expect that methodology for estimation and the standard for accuracy would similarly evolve. 2. Have you tried the Bioconductor (www.bioconductor.org/) listserve? They might be able to say something more useful than a general list like this. spencer gr...