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davor
2006 Oct 04
0
[OT] Survival and Function as co-primary endpoints in clinical trials. How to simulate in R ?
...ave a drug that improves survival this is not what you should do for
the following reasons: - Death leads to missing data on function (sic)
- This does not occur at random if the drug impacts
survival
- The assessment of function is biased in defavor of
the drug improving survival (keeping alive patients
with poor function)
and in favor of the placebo group (those who
survive have better function)
The questions: 1-Would some one please suggest litterature where thi...