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...ow p values in real world scenarios. If you agree with me, you might want to consider generally using Student's test instead, by using t.test(x, y, var.equal = TRUE). Code to demonstrate the problem and play around with different scenarios, as described in the paper, is at: https://github.com/davenomiddlenamecurtis/TestTTest Regards * Dave Curtis -- Professor David Curtis MD PhD UCL Genetics Institute University College London [[alternative HTML version deleted]]