search for: cs_a_

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2010 Feb 14
0
gnls not optimizing values
...data using the gnls function, it doesn't return optimized values of the model parameters. Instead it just returns the exact same values I used as initial guesses, but with standard errors calculated. Example is as follows: two_site_mHb <- gnls(y ~ (CS_AH2 + CS_AH1*10^(n1*(x-pKa1)) + CS_A_*10^ ((n1+1)*x-n1*pKa1-pKa2)) / (1 + 10^(n1*(x-pKa1)) + 10^((n1+1)*x- n1*pKa1-pKa2)), start=list(CS_AH2=y[1], CS_A_=y[length(y)], CS_AH1=y [length(y)/2], pKa1=3.3, pKa2=5.9, n1=1.5)) and the results are: Generalized nonlinear least squares fit Model: y ~ (CS_AH2 + CS_AH1 * 10^(n1 * (x - pKa1...