search for: clinical

Hi, Could someone help with coding this in R? I need to select one row per patient i in clinic j. The data is organized similar to that shown below. Two columns - patient i in column j identify each unique patient. There are two columns on outcome. Some patients have multiple rows with each row representing one visit, coded for in the column, visit. Some patients have just one row indicating

...ition''s major responsibilities or end results. (TYPE BELOW THIS LINE) • Support for broad implementation of innovative approaches: Implement strategy for promoting the broader utilization of innovative approaches across the development portfolio, through coordinated efforts involving clinical, operational, regulatory areas. Bring together key stakeholders from different key areas, identify potential hurdles for broader use of innovation in drug development and participate in finding solutions for them. Collaborate in talent identification for QDS group, hiring and development. Ensure fo...

Dear experts, I am asking for help with a question regarding to stratified bootstrap. My dataset is a longitudinal dataset (3 measurements per person at year 1, 4 and 7) composed of multiple clinic centers and multiple participants within each clinic. It has missing values. I want to do a bootstrap to find the standard errors and confidence intervals for my variance components. My model is a

...own subject line rather then being lost in a 60-msg-long thread... On Sun, Jan 11, 2009 at 10:08 AM, Marc Schwartz <marc_schwartz at comcast.net> wrote: ... I strongly believe that the comments regarding R and the FDA are overly negative and pessimistic. The hurdles to the use of R for clinical trials are shrinking. There has been substantive activity over the past several years, both internally at the FDA and within the R community to increase R's acceptance in this domain. At the Joint Statistical Meetings in 2006, Sue Bell from the FDA spoke during a session with a presentation en...

Alistair-- I wrote functions to calculate Clinical Significance in Splus for the following article: McGlinchey, J. B., Atkins, D. C., & Jacobson, N. S. (2002). Clinical significance methods: Which one to use and how useful are they? Behavior Therapy, 33, 529-550. I will send the functions to you back-channel. cheers, Dave -- Dave Atkin...

// ///Clinical Information Technology Research Assistant (102792) We are looking for a Clinical Information Technology Research Assistant to work on the Oxford component of the EURECA FP7 project (Enabling information re-Use by linking clinical REsearch and CAre) http://eurecaproject.eu/partners. The post-ho...

...eveloping and expanding your career. Responsibilities: - Develops, coordinates, and provides statistical leadership and support for related drug/vaccine projects in Biometrics Research. - Ensures that sound scientific principles and statistical methods are applied to designing and analyzing non-clinical and clinical studies in support of discovery and worldwide regulatory submissions. - Interacts with Clinical, Regulatory, Statistical Programming, Data Management, and other Merck Research Laboratories in coordinating the statistical activities for clinical drug/vaccine projects. May interact with...

Hello Everyone,   I’m a SAS user who has recently become interested in sequential clinical trials designs. I’ve discovered that the SAS based approaches for these designs are either too costly or are “experimental.” So now I’m looking for alternative software. Two programs that seem promising are SPLUS Seqtrial and R.   I recently obtained a 30 day trial for the SPLUS Seqtrial add-on and...

// ///Clinical Information Technology Research Assistant (102792) We are looking for a Clinical Information Technology Research Assistant to work on the Oxford component of the EURECA FP7 project (Enabling information re-Use by linking clinical REsearch and CAre). The post-holder will be in the Oxford compone...

Dear all, There have been a variety of discussions on the R list regarding the use of R in clinical trials. The following post from the STATA list provides an interesting opinion regarding why SAS remains so popular in this arena: http://www.stata.com/statalist/archive/2008-01/msg00098.html Regards, -Cody Hamilton

Hi, I have a series of id's with multiple visits and questionnaire scores. This is a clinical trial that will be analyzed using the last observation carried forward method. In other words, in order to comply with intent to treat analysis when many subjects withdraw, data points for the last visit must be generated and filled in with the last observation. The ultimate goal is to tabulate t...

...ntifying opportunities to utilize innovative designs and statistical analysis methods in drug development. She/He will be proposing/developing innovative designs and analysis methods and evaluating them via simulation studies and other appropriate instruments. This person will be interacting with clinical teams to ensure the proper implementation of innovative approaches in clinical trials and development programs. They will be participating in strategic planning and supporting the broad implementation of innovative approaches across clinical development. She/He will be providing/arranging interna...

...-0670 Overview: -Back up programming of tables, listings, and graphs for a specified compound project. -Responsible for the validation and quality assurance of any output produced for specified projects and contributing to al project management such that timelines are met. -Back up participant on Clinical Project teams representing clinical programming efforts for that clinical team. -Prefer candidate with clinical experience. -SAS program experience required. Responsibilities: -Contribute to the programming of tables and graphs for various projects related to genomics/biomarkers and discovery,...

Hi all, I happened to be reviewing a Linux web site that I frequent (http://www.pclinuxonline.com/index.php) and noted today an entry for an article on R at IBM's developerWorks Server Clinic site located at http://www-106.ibm.com/developerworks/linux/library/l-sc16.html. I thought that I would pass this on as an FYI. Regards, Marc Schwartz

...d to my last post about Schafer's MI packages. I am really pleased to have access to them through R which, I have to say, is an amazing piece of software. I am only sorry that I haven't found it until now. But, to my question. Does anyone know if there is a package developed for evaluating clinical significance using Jacobson and Truax's, or variations thereof, procedures? Cheers Alistair Campbell School of Psychology James Cook University Townsville QLD [[alternative HTML version deleted]]

...iew: -Back up contact for programming of tables, listings, and graphs for a specified compound project. -Responsible for the validation and quality assurance of any output produced for specified projects and contributing to al project management such that timelines are met. -Back up participant on Clinical Project teams representing clinical programming efforts for that clinical team. -Prefer candidate with clinical experience. -SAS program experience required. Responsibilities: -Contribute to the programming of tables and graphs for various projects related to genomics/biomarkers and discovery,...

Does anyone know if for clinical studies the FDA would accept statistical analyses performed with R ? Delphine Fontaine

I am trying to build a model to aid a clinical decision. Certain patients have a blood marker measured at each visit - a rise of this may indicate recurrence of the cancer after treatment (endpoint is "clinical recurrence", censored). In a proportion (up to 30%), this rise is a false positive - hence I wish to correlate factors at the...

Is anybody using R to do analysis of clinical trial datasets that have been put in the public domain (which are super hard to find). Not only a single data table, but the actual database, with a handful of data tables with one-to-one or many-to-one relationships? [ For example, "Adverse Events" and "Patient Info" are two d...

May I ask a clinical question? For a trial, we have a treatment group of small size, say 30 patients. We want to selectmatching control patients from a bigger group (100 patients) in terms of several clinical variables, such as age, tumor stage etc. This practice is to select the closest matching set of control case...