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...positive definite), find y such that y_i<=0 (i=1..p) minimizing the mahalanobis distance (x-y)'S^{-1}(x-y). Has anyone worked on this problem? Tips or R code would be appreciated. David ____________________ David Edwards Principal scientist Biostatistics Novo Nordisk A/S Novo Allé 2880 Bagsvaerd Denmark +45 4444 8888 (phone) This e-mail (including any attachments) is intended for the addressee(s) stated above only and may contain confidential information protected by law. You are hereby notified that any unauthorised reading, disclosure, copying or distribution of this e-mail or use of in...