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...ou recommend any literature discussing this topic? Many Thanks, Stefan The columns of matrix X dummy-codes 1. Data of Group1 (G1) 2. Data of Group2 (G2) 3. Data condition A1 (factor A) 4. Data condition A2 (factor A) 5. Data in cell A1G1 6. Data in cell A2G1 7. Data in cell A1G2 8. Data in cell A2G2 9. Data condition B1 (factor B) 10. Data condition B2 (factor B) 11. Data in cell B1G1 12. Data in cell B2G1 13. Data in cell B1G2 14. Data in cell B2G2 15. Mean Example: #create X dimnames = list( paste("sub",c(1:8)), c("Group1","Group2","A1","A2"...