Displaying 1 result from an estimated 1 matches for "056598en".
2006 Oct 04
0
[OT] Survival and Function as co-primary endpoints in clinical trials. How to simulate in R ?
...this is partly (widely ?) OT. Not sure where to
ask, R is my favorite computer tool (no kidding) and there are plenty of
knowledgable and helpful people on the list.
Background: There are discussions among experts and regulatory
authorities (cf guideline
http://www.emea.europa.eu/pdfs/human/ewp/056598en.pdf) that, in for
example Amyotrophic Lateral Sclerosis, a functional endpoint
(respiratory function, muscular testing, rating scale) should be
associated (co-primary, 2 primaries etc..) to survival in drug trials.
My problem: I wish to illustrate that from my point of view and when you
have a dru...