The error message does not say anything about having more than two predictor variables. It says that one of the combinations of the predictor variables has less than 2 observations (i.e. 1 or 0 observations). That is probably an issue of your sample size. You may need to consider combining some of the categories in your predictor variables or increasing your sample size. Are your predictor variables coded as factors? ---------------------------------------- David L Carlson Department of Anthropology Texas A&M University College Station, TX 77843-4352 -----Original Message----- From: R-help <r-help-bounces at r-project.org> On Behalf Of Yectli Huerta via R-help Sent: Monday, November 12, 2018 2:38 PM To: r-help at r-project.org Subject: [R] semiparametric manova Hello, I was wondering if there are other packages like MANOVA.RM that could be used to analysis non normal distributions. I have to analyze data with more than 2 predictor variables and a similar number of response variables. When I try the function MANOVA.wide with more than 2 predictor variables, I get There is at least one factor-level combination ?????????? with less than 2 observations! Is there another package out there that can be used to analyze the significance of more than 2 predictor variables? thanks, yah