John Kane
2015-Jul-24 13:37 UTC
[R] Differences in output of lme() when introducing interactions
I clearly am going to have to improve my stats knowledge by reading McPhearson. To heck with Senn- too complicated. :) Thanks Terry. John Kane Kingston ON Canada> -----Original Message----- > From: therneau at mayo.edu > Sent: Thu, 23 Jul 2015 14:07:00 -0500 > To: r.turner at auckland.ac.nz, therneau at mayo.edu > Subject: Re: [R] Differences in output of lme() when introducing > interactions > > The following are in parody (but like all good parody correct wrt the > salient features). > The musings of > Guernsey McPhearson > http://www.senns.demon.co.uk/wprose.html#Mixed > http://www.senns.demon.co.uk/wprose.html#FDA > > > In formal publication: > Senn, Statistical Issues in Drug Development, second edition, Chapter > 14: Multicentre Trials > Senn, The many modes of meta, Drug information journal, 34:535-549, > 2000. > > The second points out that in a meta analysis no one would ever consider > giving both large > and small trials equal weights, and relates that to several other bits of > standard > practice. The 'equal weights' notion embedded in a fixed effects model + > SAS type 3 is an > isolated backwater. > > Terry T. > > PS. The "Devils' Drug Development Dictionary" at the same source has some > gems. Three > rather random choices: > > Bayesian - One who, vaguely expecting a horse and catching a glimpse of a > donkey, strongly > concludes he has seen a mule. > > Medical Statistician - One who won't accept that Columbus discovered > America because he > said he was looking for India in the trial Plan. > > Trend Towards Significance - An ever present help in times of trouble. > > > > On 07/22/2015 06:02 PM, Rolf Turner wrote: >> On 23/07/15 01:15, Therneau, Terry M., Ph.D. wrote: >> >> <SNIP> >> >>> 3. Should you ever use it [i.e. Type III SS]? No. There is a very >>> strong inverse >>> correlation between "understand what it really is" and "recommend its >>> use". Stephen Senn has written very intellgently on the issues. >> >> Terry --- can you please supply an explicit citation? Ta. >> >> cheers, >> >> Rolf >> > > ______________________________________________ > R-help at r-project.org mailing list -- To UNSUBSCRIBE and more, see > https://stat.ethz.ch/mailman/listinfo/r-help > PLEASE do read the posting guide > http://www.R-project.org/posting-guide.html > and provide commented, minimal, self-contained, reproducible code.____________________________________________________________ FREE ONLINE PHOTOSHARING - Share your photos online with your friends and family! Visit http://www.inbox.com/photosharing to find out more!